1. Autophagy
    Apoptosis
  2. Autophagy
    Apoptosis
  3. Dioscin

Dioscin (Synonyms: Collettiside III; CCRIS 4123)

Cat. No.: HY-N0124 Purity: 98.33%
Handling Instructions

Dioscin(CCRIS 4123; Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines.

For research use only. We do not sell to patients.

Dioscin Chemical Structure

Dioscin Chemical Structure

CAS No. : 19057-60-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 76 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
50 mg USD 290 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 7 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Dioscin purchased from MCE. Usage Cited in: Mol Med Rep. 2017 Oct;16(4):4922-4926.

    Dioscin concentrations of 0.5, 1, 5, 10 and 25 µg/mL promotes the expression of ALP and inhibits the expression of LC3B in MC3T3-E1 cells, in a concentration-dependent manner.
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    Description

    Dioscin(CCRIS 4123; Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines. IC50 value: Target: Anticancer agent in vitro: dioscin (1, 2 and 4 μmol/L) could significantly inhibit the viability of LNCaP cells in a time- and concentration-dependent manner. Flow cytometry revealed that the apoptosis rate was increased after treatment of LNCaP cells with dioscin for 24 h, indicating that apoptosis was an important mechanism by which dioscin inhibited cancer [1]. dioscin abrogated AKT phosphorylation, which subsequently impaired RANKL-induced nuclear factor-kappaB (NF-κB) signaling pathway and inhibited NFATc1 transcriptional activity. Moreover, in vivo studies further verified the bone protection activity of dioscin in osteolytic animal model [2]. Dioscin reduced cell death and lactate dehydrogenase (LDH) release in cells subjected to I/R. I/R induced apoptosis and cytochrome c release from mitochondria to the cytosol and this was prevented by dioscin. In support, dioscin decreased Bax but increased Bcl-2 mRNA expression. Dioscin prevented I/R induced dissipation of ΔΨm [3].

    Molecular Weight

    869.04

    Formula

    C₄₅H₇₂O₁₆

    CAS No.
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    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (115.07 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1507 mL 5.7535 mL 11.5070 mL
    5 mM 0.2301 mL 1.1507 mL 2.3014 mL
    10 mM 0.1151 mL 0.5753 mL 1.1507 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.25 mg/mL (2.59 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.25 mg/mL (2.59 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.25 mg/mL (2.59 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 98.33%

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    Keywords:

    DioscinCollettiside III CCRIS 4123CCRIS4123CCRIS 4123CCRIS-4123AutophagyApoptosisInhibitorinhibitorinhibit

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    Product Name:
    Dioscin
    Cat. No.:
    HY-N0124
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