Synthesis of 5(6)-dihydro-OSW-1 analogs bearing three kinds of disaccharides linking at 15-hydroxy and their antitumor activities

  • Bioorg Med Chem Lett. 2011 May 15;21(10):2921-4. doi: 10.1016/j.bmcl.2011.03.065.
Yuyao Guan  1 ,  Dan Zheng ,  Liang Zhou ,  Haixing Wang ,  Zheng Yan ,  Nan Wang ,  Hong Chang ,  Pingping She ,  Pingsheng Lei
Affiliations
  • 1. Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Peking 100050, PR China.
PMID: 21482468 DOI: 10.1016/j.bmcl.2011.03.065
Abstract

In order to study the SAR of 5(6)-dihydro-OSW-1, eight 15(α)β-O-glycosyl analogs (26-33) carrying three kinds of disaccharides including [β-d-Xylp-(1-3)-α-l-Arap], [β-d-Xylp-(1-4)-α-l-Arap] and [α-l-Rhap-(1-2)-(α)β-d-Glcp] were designed and synthesized. Their in vitro antitumor activities were tested by the standard MTT assay which disclosed that compound 33 (IC(50)=0.28-0.52 μM) showed potential antitumor activities.