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NaPi2b-IN-3 

Cat. No.: HY-146429
Handling Instructions

NaPi2b-IN-3 (compound 5) is a potent sodium-dependent transport protein 2b (SLC34A2, NaPi2b) inhibitor with IC50s of 71 nM and 28 nM for human NaPi2b and rat NaPi2b, respectively. NaPi2b-IN-3 can be used for researching hyperphosphatemia.

For research use only. We do not sell to patients.

NaPi2b-IN-3 Chemical Structure

NaPi2b-IN-3 Chemical Structure

CAS No. : 2227443-66-3

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Description

NaPi2b-IN-3 (compound 5) is a potent sodium-dependent transport protein 2b (SLC34A2, NaPi2b) inhibitor with IC50s of 71 nM and 28 nM for human NaPi2b and rat NaPi2b, respectively. NaPi2b-IN-3 can be used for researching hyperphosphatemia[1].

In Vivo

NaPi2b-IN-3 (1 mg/kg for IV and 10mg/kg for PO; single dosage) exhibits good activity and moderate hydrophobicity, and systemically exposes to some extent[1].
Pharmacokinetic Parameters of NaPi2b-IN-3 in male Sprague-Dawley rats[1].

IV (1 mg/kg) PO (10 mg/kg)
AUC0-t (h·ng/mL) 834 ± 353 1090 ± 430
Cmax (ng/mL) 568 ± 261
F (%) 13.1

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[1]
Dosage: 1 and 10 mg/kg
Administration: IV and PO; single dosage
Result: Exhibited good activity and moderate hydrophobicity and systemically exposed to some extent.
Molecular Weight

773.92

Formula

C45H51N5O7

CAS No.
SMILES

CCC(N(CC1=CC(C(NC2=C(C3=C(N2)C=CC=C3)C(NC4=CC=C(C=C4)CCCC5=CC=C(C=C5)C(O)=O)=O)=O)=CC=C1)CCN(C(CCC(O)=O)=O)C)CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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NaPi2b-IN-3
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