1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Nav1.8 Isoform

Nav1.8

 

Nav1.8 Related Products (11):

Cat. No. Product Name Effect Purity
  • HY-11079
    A-803467
    Inhibitor 99.09%
    A-803467 is a potent and selective tetrodotoxin-resistant Nav1.8 sodium channel blocker (IC50=8 nM).
  • HY-16787
    ICA-121431
    Inhibitor 98.45%
    ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively.
  • HY-139346
    VX-150
    Inhibitor 98.00%
    VX-150 is an orally active, highly selective NaV1.8 inhibitor.
  • HY-114301
    PF-06305591
    Inhibitor 99.92%
    PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM.
  • HY-105283
    PF 04531083
    Antagonist 98.96%
    PF 04531083 is a selective NaV1.8 blocker, and used for the research of neuropathic/inflammatory pain.
  • HY-114301A
    PF-06305591 dihydrate
    Inhibitor ≥99.0%
    PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM.
  • HY-100080
    A-887826
    Inhibitor 99.76%
    A-887826 is a potent, selective, oral bioavailable and voltage-dependent Na(v)1.8 sodium channel blocker with an IC50 of 11 nM .
  • HY-107405
    TC-N 1752
    Inhibitor 99.18%
    TC-N 1752 is a potent and orally active inhibitor of Nav1.7, with IC50s of 0.17 μM, 0.3 μM, 0.4 μM, 1.1 μM and 2.2 μM at hNav1.7, hNav1.3, hNav1.4, hNaV1.5 and rNav1.8, respectively.
  • HY-146069
    ABBV-318
    Inhibitor
    ABBV-318 is a potent Nav1.7/ Nav1.8 blocker, with IC50s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively.
  • HY-143481
    Nav1.8-IN-2
    Inhibitor
    Nav1.8-IN-2 (compound 35A) is a potent Nav1.8 inhibitor with an IC50 value of 0.4 nM.
  • HY-B1837
    Cyfluthrin
    Inhibitor
    Cyfluthrin is a type II pyrethroid and has effects on various insects.