2417328-24-4
2417328-24-4
Chemical Structure
MK-5661
- CAS No.: 2417328-24-4
- Formula:C18H18F5N5O3S
- Molecular Weight:479.42
InChIKey: YPDVFXNLSOAQIY-JTQLQIEISA-N
SMILES: C[C@H]1CN(CCC1(F)F)C2=NC=C(C=C2C(NC3=CC(S(N)(=O)=O)=NC=C3)=O)C(F)(F)F
Biological Activity: MK-5661 is an orally potent NaV1.8 voltage-gated sodium channel inhibitor with an EC50 of 4.3 nM. MK-5661 selectively inhibits peripheral nociceptive signaling mediators. MK-5661 reduces capsaicin-induced spontaneous nociceptive behaviors in humanized rats and attenuates capsaicin-induced skin flushing responses in rhesus monkeys. MK-5661 is applicable for pain-related research[1].
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MK-5661 | MK-5661 is an orally potent NaV1.8 voltage-gated sodium channel inhibitor with an EC50 of 4.3 nM. MK-5661 selectively inhibits peripheral nociceptive signaling mediators. MK-5661 reduces capsaicin-induced spontaneous nociceptive behaviors in humanized rats and attenuates capsaicin-induced skin flushing responses in rhesus monkeys. MK-5661 is applicable for pain-related research. | |||||||||||||||||||||
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