1. Autophagy
  2. LRRK2
  3. PF-06456384 trihydrochloride

PF-06456384 trihydrochloride 

Cat. No.: HY-118952A Purity: 99.77%
Handling Instructions

PF-06447475 trihydrochloride is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 trihydrochloride can be used for parkinson's disease (PD) research.

For research use only. We do not sell to patients.

PF-06456384 trihydrochloride Chemical Structure

PF-06456384 trihydrochloride Chemical Structure

CAS No. : 1834610-75-1

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Free Sample (0.5-1 mg)   Apply Now  
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
25 mg USD 360 In-stock
Estimated Time of Arrival: December 31
50 mg USD 624 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1080 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PF-06456384 trihydrochloride:

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Description

PF-06447475 trihydrochloride is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 trihydrochloride can be used for parkinson's disease (PD) research[1].

Molecular Weight

829.18

Formula

C35H35Cl3F3N7O3S2

CAS No.
SMILES

N#CC1=CC(S(=O)(NC2=NC=NS2)=O)=CC=C1OC3=CC=C(C4=CC(C(F)(F)F)=CC=C4)C=C3C5=CC(CNCCC6CCNCC6)=NC=C5.[H]Cl.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (150.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2060 mL 6.0301 mL 12.0601 mL
5 mM 0.2412 mL 1.2060 mL 2.4120 mL
10 mM 0.1206 mL 0.6030 mL 1.2060 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Product Name:
PF-06456384 trihydrochloride
Cat. No.:
HY-118952A
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