2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Sodium Channel
  5. Nav1.9 Isoform

Nav1.9

Naᵥ1.9, encoded by SCN11A, is preferentially expressed in peripheral nociceptive neurons and visceral afferents, where it acts as a threshold channel[1]. Mechanistically, Naᵥ1.9 produces persistent tetrodotoxin-resistant current that modulates resting potential and amplifies small depolarizations[2]. In inflammatory pain models, Naᵥ1.9 contributes to persistent thermal hypersensitivity and spontaneous pain behavior after peripheral inflammation[3]. Human disease evidence links SCN11A gain-of-function variants to familial episodic pain and painful peripheral neuropathy[4][1]. Compared with Naᵥ1.7 and Naᵥ1.8, Naᵥ1.9 shows unique gating and pharmacology, including hyperpolarized activation, slow inactivation, and limited recombinant-channel pharmacology before stable HEK-293 expression systems[5]. For experimental applications, stable human, mouse, and rat Naᵥ1.9 HEK-293 cell lines support biophysical analysis and inhibitor characterization[5].- Naᵥ1.9 research should prioritize nociceptor excitability, inflammatory pain, and SCN11A channelopathy models. - Stable recombinant systems enable controlled testing of Naᵥ1.9 gating, species differences, and inhibitor responses.

Nav1.9 Related Products (2):

Cat. No. Product Name Effect Purity
  • HY-125079
    DSP-2230
    		Inhibitor 98.33%
    DSP-2230 is the orally active inhibitor for voltage-gated sodium channel that inhibits Nav1.7-, Nav1.8-, and Nav1.9-derived sodium currents with IC50s of 7.1 μM, 11.4 μM and 6.7 μM, respectively. DSP-2230 can be used to improve neuropathic pain.
  • HY-178281
    E0199
    		Inhibitor 99.89%
    E0199 is a novel potent dual-target KV7/NaV modulator that activates the KV7 channel (KV7.2/7.3 (EC50 = 12.78 nM), KV7.2 (EC50 = 0.50 μM), and KV7.5 (EC50 = 27.14 nM) channels) while simultaneously blocks the NaV1.7 (IC50 = 0.52 μM), NaV1.8 (IC50 = 0.24 μM), and NaV1.9 (IC50 = 0.16 μM) channels. E0199 shows a potent analgesic effect without affecting heart and skeletal muscle ion channels critically in a chronic constriction injury (CCI) mouse model. E0199 can be used for Neuropathic pain (NP) research.