Na_v1.7

Na_v1.7 Related Products (21):

By Type:	Pan (5) Selective (12)
By Effects:	Inhibitors (17) Antagonists (4)

Cat. No.	Product Name	Effect	Purity

HY-N6691

Veratridine	Inhibitor	99.96%
Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) blocker.

HY-16723

Funapide	Inhibitor	99.72%
Funapide (TV 45070; XEN402) is a potent Sodium Channel Nav1.7 inhibitor.

HY-131182

DS-1971a	Inhibitor	99.66%
DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC₅₀s of 22.8 and 59.4 nM for hNaV1.7 and mNaV1.7, respectively.

HY-112279

GNE-131	Inhibitor	98.97%
GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC₅₀ of 3 nM.

HY-131870

GX-201	Inhibitor	99.14%
GX-201 is a selective Na_V1.7 inhibitor, with an IC₅₀ of <3.2 nM for hNa_V1.7.

HY-16723A

(R)-Funapide	Inhibitor	98.05%
(R)-Funapide ((R)-TV 45070) is the less active R-enantiomer of Funapide.

HY-139081

GDC-0310	Inhibitor	99.80%
GDC-0310 is a selective acyl-sulfonamide Na_v1.7 inhibitor, with an IC₅₀ of 0.6 nM for hNa_v1.7.

HY-19366

Nav1.7-IN-2	Inhibitor	99.81%
Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM.

HY-107405

TC-N 1752	Inhibitor	99.18%
TC-N 1752 is a potent and orally active inhibitor of Nav1.7, with IC₅₀s of 0.17 μM, 0.3 μM, 0.4 μM, 1.1 μM and 2.2 μM at hNav1.7, hNav1.3, hNav1.4, hNaV1.5 and rNav1.8, respectively.

HY-108425

AMG8379	Antagonist
AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1.7, with IC₅₀s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively.

HY-12883A

PF-05198007	Inhibitor	99.77%
PF-05198007 is a potent, orally active and selective arylsulfonamide Na_v1.7 inhibitor.

HY-146069

ABBV-318	Inhibitor	98.97%
ABBV-318 is a potent Nav1.7/ Nav1.8 blocker, with IC₅₀s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively.

HY-126291

GNE-616	Inhibitor
GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype selective Nav1.7 inhibitor (K_i of 0.79 nM and K_d of 0.38 nM for hNav1.7) for the treatment of chronic pain.

HY-108425B

(Rac)-AMG8379	Antagonist
(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379.

HY-119934

NaV1.7 inhibitor-1	Inhibitor	99.65%
NaV1.7 inhibitor-1 is an efficacious voltage-gated sodium channel (NaV) 1.7 inhibitor with an IC₅₀ of 0.6 nM for hNaV1.7, exhibits 80-fold selectivity versus hNaV1.5.

HY-118048

NAV 26	Inhibitor
NAV 26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC₅₀ of 0.37 μM.

HY-108425A

AMG8380	Antagonist
AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control.

HY-141547

Nav1.7-IN-8	Inhibitor
Nav1.7-IN-8 is a potent blockage of NaV1.7 with high selectivity for the inhibition of NaV1.7 over the subtypes hNaV1.1 and hNaV1.5.

HY-P1220

Huwentoxin-IV	Inhibitor
Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC₅₀s of 26, 150, 338 and 400 nM, respectively.

HY-P1220A

Huwentoxin-IV TFA	Inhibitor
Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC₅₀s of 26, 150, 338 and 400 nM, respectively.

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