2241651-99-8
Chemical Structure
AZ194
- CAS No.: 2241651-99-8
- Formula:C34H31F2N3O3
- Molecular Weight:567.63
IUPAC Name: (4-(1-(3-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-((3-fluorobenzyl)oxy)-3-methoxyphenyl)methanone
InChIKey: HDKZBBHJFURFLF-UHFFFAOYSA-N
SMILES: O=C(N1CCC(CC1)C2=NC3=C(N2CC4=CC(F)=CC=C4)C=CC=C3)C5=CC=C(C(OC)=C5)OCC6=CC(F)=CC=C6
Biological Activity: AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and inhibitor of NaV1.7 (IC50=1.2 μM). AZ194 blocks SUMOylation of CRMP2 to selectively reduce the amount of surface-expressed NaV1.7. Antinociceptive effects[1].
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AZ194 | 99.45% | AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and inhibitor of NaV1.7 (IC50=1.2 μM). AZ194 blocks SUMOylation of CRMP2 to selectively reduce the amount of surface-expressed NaV1.7. Antinociceptive effects. | ||||||||||||||||||||
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Keywords
