71-62-5
71-62-5
Chemical Structure
Veratridine
Synonym(s): 3-Veratroylveracevine
- CAS No.: 71-62-5
- Formula:C36H51NO11
- Molecular Weight:673.79
IUPAC Name: (3S,4S,4aS,6aS,6bR,8S,8aS,9R,9aS,12S,15aS,15bR,16aR,16bS)-4,6b,8,8a,9,15b-hexahydroxy-9,12,16b-trimethyldocosahydro-2H-4,16a-epoxybenzo[4,5]indeno[1,2-h]pyrido[1,2-b]isoquinolin-3-yl 3,4-dimethoxybenzoate
InChIKey: FVECELJHCSPHKY-YFUMOZOISA-N
SMILES: C[C@@]12[C@]34[C@](CC[C@]1([H])[C@@](O)([C@@H](OC(C5=CC(OC)=C(OC)C=C5)=O)CC2)O4)([H])[C@@]6(O)[C@](O)([C@@]7([H])[C@@](O)([C@](O)([C@@]8([H])N(C[C@@H](C)CC8)C7)C)[C@@H](O)C6)C3
Biological Activity: Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow[1][2].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Veratridine | 99.42% | Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow. | ||||||||||||||||||||
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Veratridine (Standard) | ≥98% | Veratridine (Standard) is the analytical standard of Veratridine. This product is intended for research and analytical applications. Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39?μM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow. | ||||||||||||||||||||
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Protoveratrine A | 99.90% | Protoveratrine A (NSC 7526; Protalba; Protoveratrin) is an alkaloid with strong cardiostimulant and vasoconstrictive effects, which can be used in the study of hypertension and other cardiovascular diseases. | ||||||||||||||||||||
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Cevine | Cevine (Sabadinine) is an alkaloid that can be isolated from sabadilla. | |||||||||||||||||||||
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Yunaconitine | 99.47% | Yunaconitine(Guayewuanine B) is a highly toxic aconitum alkaloid. | ||||||||||||||||||||
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Forestine | 98.44% | Forestine is a natural C19-diterpenoid alkaloid found in the roots of Aconitum forrestii Stapf. | ||||||||||||||||||||
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Cevadine | 98.76% | Cevadine is a voltage-sensitive sodium channel agonist. Cevadine has insecticidal activity. | ||||||||||||||||||||
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O-Deacetylfalconericine | O-Deacetylfalconericine is a natural product. | |||||||||||||||||||||
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3β-Vanilloyloxy-21β,29-dihydroxyserrat-14-en-24-oic acid | 3β-Vanilloyloxy-21β,29-dihydroxyserrat-14-en-24-oic acid is a natural triterpene. | |||||||||||||||||||||
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Mudanpioside E | Mudanpioside E is an orally effective paeoniflorin-type monoterpene glycoside antiallergic agent, with an IC50 of 40.34 μM against IgE-mediated β-hexosaminidase release. Mudanpioside E reverses the inhibitory effect of the modified Xiaoqinglong Decoction extract (paeonia root component removed) on passive cutaneous anaphylaxis in mice. Mudanpioside E itself shows no activity against passive cutaneous anaphylaxis. Mudanpioside E can be used in research related to allergic diseases. | |||||||||||||||||||||
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Crassicauline A (Standard) | ≥98% | Crassicauline A (Crassicaulin A) Standard is the analytical standard of Crassicauline A (HY-N1924). This product is intended for research and analytical applications. Crassicauline A (Crassicaulin A) is a diester-type diterpenoid alkaloid. Crassicauline A exhibits feeding deterrent activity against adult Tribolium castaneum, with a EC50 of 1134.5 ppm. Crassicauline A induces arrhythmia at a dose of 0.10 mg/kg. | ||||||||||||||||||||
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8-Deacetylyunaconitine | 98.89% | 8-Deacetylyunaconitine, a diterpenoid alkaloid, can be found in the root extract of A. forrestii. | ||||||||||||||||||||
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References
- [1]. Zhang XY, et al. Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7. Acta Pharmacol Sin. 2018 Nov;39(11):1716-1724. [Content Brief]
- [2]. Laura A Uribe, et al. Supramolecular Complexes of Plant Neurotoxin Veratridine with Cyclodextrins and Their Antidote-like Effect on Neuro-2a Cell Viability. Pharmaceutics. 2022 Mar 9;14(3):598. [Content Brief]
