2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. Mudanpioside E

Mudanpioside E is an orally effective paeoniflorin-type monoterpene glycoside antiallergic agent, with an IC50 of 40.34 μM against IgE-mediated β-hexosaminidase release. Mudanpioside E reverses the inhibitory effect of the modified Xiaoqinglong Decoction extract (paeonia root component removed) on passive cutaneous anaphylaxis in mice. Mudanpioside E itself shows no activity against passive cutaneous anaphylaxis. Mudanpioside E can be used in research related to allergic diseases.

For research use only. We do not sell to patients.

Mudanpioside E

Mudanpioside E Chemical Structure

CAS No. : 172705-25-8

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Mudanpioside E Related Antibodies

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Description

Mudanpioside E is an orally effective paeoniflorin-type monoterpene glycoside antiallergic agent, with an IC50 of 40.34 μM against IgE-mediated β-hexosaminidase release. Mudanpioside E reverses the inhibitory effect of the modified Xiaoqinglong Decoction extract (paeonia root component removed) on passive cutaneous anaphylaxis in mice. Mudanpioside E itself shows no activity against passive cutaneous anaphylaxis. Mudanpioside E can be used in research related to allergic diseases[1][2].

In Vitro

Mudanpioside E (10.0-100.0 μM) potently inhibits IgE-mediated β-hexosaminidase release (a marker of degranulation) in RBL-2H3 cells, with an IC50 of 40.34 μM, and shows no cytotoxicity even at concentrations as high as 100.0 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mudanpioside E Related Antibodies
In Vivo

Mudanpioside E (0.55 g/kg-2.2 mg/kg; p.o.; single administration) dose-dependently abrogates the inhibitory effect of the modified Xiaoqinglong Decoction extract (with paeoniflorin removed) on passive cutaneous anaphylaxis (PCA) in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ddY mice (6-week-old, male)[1]
Dosage: 0.55 mg/kg; 1.1 mg/kg; 2.2 mg/kg (all co-administered with Peony root-depleted Shoseiryuto-extract at 0.57 g/kg)
Administration: p.o.; single dose
Result: Significantly counteracted the suppressive effect of Peony root-depleted Shoseiryuto-extract on the PCA reaction in a dose-dependent manner at 0.55, 1.1, and 2.2 mg/kg.
Did not exhibit any effect on the PCA reaction when administered alone at 2.2 mg/kg.
Molecular Weight

526.49

Formula

C24H30O13
CAS No.
SMILES

O=C(C1=CC(OC)=C(C=C1)O)OC[C@@]23[C@]4([C@]5(O[C@]2([H])O[C@@]([C@]3([H])C4)(C5)O)C)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO
Structure Classification
Initial Source
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Storage

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Purity & Documentation
References
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Mudanpioside E Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mudanpioside E172705-25-8Glycosidasebasophil leukemia cellsallergic diseasesIgE-mediated β-hexosaminidase releasedegranulationPaeonia lactiflora 'Edulis Superba'miceRBL-2H3 cellspassive cutaneous anaphylaxis reactionsInhibitorinhibitorinhibit

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