1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. GX-201

GX-201 

Cat. No.: HY-131870
Handling Instructions

GX-201 is a selective NaV1.7 inhibitor, with an IC50 of <3.2 nM for hNaV1.7.

For research use only. We do not sell to patients.

GX-201 Chemical Structure

GX-201 Chemical Structure

CAS No. : 1788071-27-1

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Description

GX-201 is a selective NaV1.7 inhibitor, with an IC50 of <3.2 nM for hNaV1.7[1].

In Vivo

GX-201 has a relatively long half-life in mice[1].
GX-201 produces analgesia at a free plasma concentration about 3 times the IC50 for high-affinity channel block[1].
GX-201 inhibits nociceptive responses induced by formalin and inflammatory pain caused by complete Freund’s adjuvant (CFA)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-Type Mice[1].
Dosage: 0.3, 1, 3 mg/kg.
Administration: Orally, once.
Result: Produced a dose-dependent inhibition of the nociceptive events.
Molecular Weight

563.00

Formula

C₂₅H₂₇ClF₄N₂O₄S

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
GX-201
Cat. No.:
HY-131870
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