1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Nav1.7-IN-3

Nav1.7-IN-3 

Cat. No.: HY-101789
Handling Instructions

Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration.

For research use only. We do not sell to patients.

Nav1.7-IN-3 Chemical Structure

Nav1.7-IN-3 Chemical Structure

CAS No. : 1788872-06-9

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Description

Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration[1].

IC50 & Target

IC50: 8 nM (Nav1.7)[1]

In Vivo

Nav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a rodent pain model (30 mg/kg, oral, 35 minutes), and efficacy in a mouse itch model (30 mg/kg, oral, 30 minutes)[1].

Animal Model: C57BL/6 male mice (n=8/group, 25-30g)
Dosage: 1, 3, and 10 mg/kg
Administration: Oral (0-35 mintues)
Result: Nav1.7-IN-3 demonstrates statistically significant, dose-dependent reversal of these effects in the acute phase of the experiment (0-5 min period post formalin injection) and the tonic phase of the experiment (20-35 min period post formalin injection) with full reversal of formalin effects in the tonic phase[1]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

430.95

Formula

C₁₇H₂₀ClFN₄O₂S₂

CAS No.

1788872-06-9

SMILES

FC1=C(S(=O)(NC2=NC=CS2)=O)C=C(Cl)C(NCC34CCCN3CCC4)=C1

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Nav1.7-IN-3
Cat. No.:
HY-101789
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Nav1.7-IN-3

Cat. No.: HY-101789