1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. XEN907

XEN907 

Cat. No.: HY-19958 Purity: 99.55%
Handling Instructions

XEN907 is a potent and spirooxindole blocker of NaV1.7, with an IC50 of 3 nM. XEN907 also inhibits CYP3A4 in a recombinant human enzyme assay. XEN907 can be used for the research of pain.

For research use only. We do not sell to patients.

XEN907 Chemical Structure

XEN907 Chemical Structure

CAS No. : 912656-34-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

XEN907 is a potent and spirooxindole blocker of NaV1.7, with an IC50 of 3 nM. XEN907 also inhibits CYP3A4 in a recombinant human enzyme assay. XEN907 can be used for the research of pain[1][2].

IC50 & Target

IC50: 3 nM (NaV1.7)[1]

In Vitro

XEN907 is not cytotoxic in HepG2 cells (% viable after 16 h: >99%)[1].
XEN907 shows moderate hepatocyte stability (% remaining after 2 h: rat 21%; human 34%; dog 46%) across species[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

XEN907 (10 mg/kg; p.o.) exhibits moderate oral bioavailability (13 %), Cmax (35 ng/mL), and AUClast (143 h•ng/mL) in rats[1].
XEN907 (3 mg/kg; i.v.) exhibits terminal elimination half-life (2.6 h), high plasma clearance (9.4 L/h/kg), and large volumes of distribution (35.0 L/kg) in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

351.40

Formula

C₂₁H₂₁NO₄

CAS No.
SMILES

O=C(C12COC3=C1C=C(OCO4)C4=C3)N(CCCCC)C5=C2C=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

XEN907XEN 907XEN-907Sodium ChannelNa channelsNa+ channelsspirooxindoleNaV1.7CYP3A4painInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
XEN907
Cat. No.:
HY-19958
Quantity:
MCE Japan Authorized Agent: