912656-34-9
912656-34-9
Chemical Structure
XEN907
- CAS No.: 912656-34-9
- Formula:C21H21NO4
- Molecular Weight:351.40
IUPAC Name: 1-pentyl-6'H-spiro[indoline-3,7'-[1,3]dioxolo[4,5-f]benzofuran]-2-one
InChIKey: PHMRUZIIERITEP-UHFFFAOYSA-N
SMILES: O=C(C12COC3=C1C=C(OCO4)C4=C3)N(CCCCC)C5=C2C=CC=C5
Biological Activity: XEN907 is a potent and spirooxindole blocker of NaV1.7, with an IC50 of 3 nM. XEN907 also inhibits CYP3A4 in a recombinant human enzyme assay. XEN907 can be used for the research of pain[1][2].
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XEN907 | 98.74% | XEN907 is a potent and spirooxindole blocker of NaV1.7, with an IC50 of 3 nM. XEN907 also inhibits CYP3A4 in a recombinant human enzyme assay. XEN907 can be used for the research of pain. | ||||||||||||||||||||
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References
- [1]. Chowdhury S, et al. Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3676-81. [Content Brief]
- [2]. Chowdhury S, et, al. Tetracyclic spirooxindole blockers of hNaV1.7: activity in vitro and in CFA-induced inflammatory pain model. Med Chem Res (2013) 22:1825–1836.
