1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. DS-1971a

DS-1971a 

Cat. No.: HY-131182
Handling Instructions

DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects.

For research use only. We do not sell to patients.

DS-1971a Chemical Structure

DS-1971a Chemical Structure

CAS No. : 1450595-86-4

Size Price Stock Quantity
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects[1].

IC50 & Target

IC50: 22.8 nM (hNaV1.7), 59.4 nM (mNaV1.7)[1]

In Vivo

DS-1971a exhibits a favorable toxicological profile[1].
DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Slc:ddY mice (PSL model)[1]
Dosage: 0.1, 0.3, and 1 mg/kg
Administration: P.o.
Result: A significant dose-dependent suppression of thermal hyperalgesiain 0.3 and 1 mg/kg administered groups. The ED50 of DS-1971a at the peak efficacy was 0.32 mg/kg.
Clinical Trial
Molecular Weight

465.93

Formula

C₂₀H₂₁ClFN₅O₃S

CAS No.

1450595-86-4

SMILES

O=S(C1=CC(Cl)=C(O[[email protected]@H]2[[email protected]@H](C3=CC=NN3C)CCCC2)C=C1F)(NC4=NC=NC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DS-1971aSodium ChannelNa channelsNa+ channelsthermalhyperalgesiamechanicalhypersensitivitytoxicityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
DS-1971a
Cat. No.:
HY-131182
Quantity:
MCE Japan Authorized Agent: