1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. PF-04856264

PF-04856264 

Cat. No.: HY-12811 Purity: 98.99%
Handling Instructions

PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC50s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. PF-04856264 shows analgesic effect.

For research use only. We do not sell to patients.

PF-04856264 Chemical Structure

PF-04856264 Chemical Structure

CAS No. : 1235397-05-3

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5 mg USD 504 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC50s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. PF-04856264 shows analgesic effect[1][2].

IC50 & Target

IC50: 28 (human Nav1.7), 131 nM (mouse Nav1.7), 19 nM (cynomolgus monkey Nav1.7), 42 nM (dog Nav1.7)[1]

In Vivo

PF-04856264 (3-30 mg/kg; i.p.) reverses OD1-induced pain behaviors[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks adult male C57BL/6J mice (OD1-induced spontaneous pain model)[2]
Dosage: 3, 30 mg/kg
Administration: I.p.
Result: Significantly reduced spontaneous pain behaviors in mice.
Molecular Weight

437.49

Formula

C₂₀H₁₅N₅O₃S₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (571.44 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2858 mL 11.4288 mL 22.8577 mL
5 mM 0.4572 mL 2.2858 mL 4.5715 mL
10 mM 0.2286 mL 1.1429 mL 2.2858 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥99.0%

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Product Name:
PF-04856264
Cat. No.:
HY-12811
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