1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. PF-06305591

PF-06305591 

Cat. No.: HY-114301 Purity: >99.0%
Handling Instructions

PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile.

For research use only. We do not sell to patients.

PF-06305591 Chemical Structure

PF-06305591 Chemical Structure

CAS No. : 1449473-97-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Description

PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile[1].

IC50 & Target

IC50: 15 nM (NaV1.8)[1].

In Vitro

PF-06305591 (compound 9) has a highly attractive profile with respect to NaV selectivity, hERG activity, passive permeability and in vitro metabolic stability[1].

In Vivo

PF-06305591 (compound 9) has good rat bioavailability. PF-06305591 offers the possibility of investigating higher IC50 multiples of Nav1.8 blockade in the clinic, and therefore a more thorough evaluation of the role of NaV1.8 in the treatment of pain[1].

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
Molecular Weight

274.36

Formula

C₁₅H₂₂N₄O

CAS No.

1449473-97-5

SMILES

CC(C)(C)C1=CC=C(NC([[email protected]]([[email protected]@H](C)C(N)=O)N)=N2)C2=C1

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >99.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
PF-06305591
Cat. No.:
HY-114301
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PF-06305591

Cat. No.: HY-114301