1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. PF-06305591 dihydrate

PF-06305591 dihydrate 

Cat. No.: HY-114301A Purity: >99.0%
Handling Instructions

PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile.

For research use only. We do not sell to patients.

PF-06305591 dihydrate Chemical Structure

PF-06305591 dihydrate Chemical Structure

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Description

PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile[1].

IC50 & Target

IC50: 15 nM (NaV1.8)[1].

In Vitro

PF-06305591 (compound 9) has a highly attractive profile with respect to NaV selectivity, hERG activity, passive permeability and in vitro metabolic stability[1].

In Vivo

PF-06305591 (compound 9) has good rat bioavailability. PF-06305591 offers the possibility of investigating higher IC50 multiples of Nav1.8 blockade in the clinic, and therefore a more thorough evaluation of the role of NaV1.8 in the treatment of pain[1].

Molecular Weight

310.39

Formula

C₁₅H₂₆N₄O₃

SMILES

CC(C)(C)C1=CC=C(NC([[email protected]]([[email protected]@H](C)C(N)=O)N)=N2)C2=C1.[H]O[H].[H]O[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: >99.0%

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Keywords:

PF-06305591 dihydrateSodium ChannelNa channelsNa+ channelsNaV1.8painInhibitorinhibitorinhibit

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PF-06305591 dihydrate
Cat. No.:
HY-114301A
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