1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. PF 04531083

PF 04531083 

Cat. No.: HY-105283 Purity: 98.24%
Handling Instructions

PF 04531083 is a selective NaV1.8 blocker, and used for the research of neuropathic/inflammatory pain.

For research use only. We do not sell to patients.

PF 04531083 Chemical Structure

PF 04531083 Chemical Structure

CAS No. : 1079400-07-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

PF 04531083 is a selective NaV1.8 blocker, and used for the research of neuropathic/inflammatory pain.

IC50 & Target

NaV1.8[1]

Clinical Trial
Molecular Weight

357.79

Formula

C₁₇H₁₆ClN₅O₂

CAS No.

1079400-07-9

SMILES

ClC1=CC=C(OC)C=C1C2=C(N=C(NC(C3=CC=NN3C)=O)C=C2)N

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (349.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7949 mL 13.9747 mL 27.9494 mL
5 mM 0.5590 mL 2.7949 mL 5.5899 mL
10 mM 0.2795 mL 1.3975 mL 2.7949 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.81 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.81 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.24%

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
PF 04531083
Cat. No.:
HY-105283
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