1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor
  3. Ziprasidone hydrochloride

Ziprasidone hydrochloride (Synonyms: CP-88059 hydrochloride)

Cat. No.: HY-14542A
Handling Instructions

Ziprasidone (CP-88059) hydrochloride, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist. Ziprasidone hydrochloride has high affinity for rat (Ki: 3.4 nM)/human (2.5 nM) 5-HT1A receptors, 5-HT2A (0.42 nM), and dopamine D2 receptors (4.8 nM). Ziprasidone hydrochloride is an inhibitor of norepinephrine reuptake.

For research use only. We do not sell to patients.

Ziprasidone hydrochloride Chemical Structure

Ziprasidone hydrochloride Chemical Structure

CAS No. : 122883-93-6

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Description

Ziprasidone (CP-88059) hydrochloride, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist. Ziprasidone hydrochloride has high affinity for rat (Ki: 3.4 nM)/human (2.5 nM) 5-HT1A receptors, 5-HT2A (0.42 nM), and dopamine D2 receptors (4.8 nM). Ziprasidone hydrochloride is an inhibitor of norepinephrine reuptake[1][2].

IC50 & Target[1] [1] [1][2]

Rat 5-HT1A Receptor

3.4 nM (Ki)

human 5-HT1A Receptor

2.5 nM (Ki)

Rat 5-HT2A

0.42 nM (Ki)

Rat D2 Receptor

4.8 nM (Ki)

In Vitro

Ziprasidone is a 5-HT1A receptor agonist and an antagonist at 5-HT2A, 5-HT2C and 5-HT1B/1D receptors. Ziprasidone has high affinity for the 5-HT1A, 5-HT1D and 5-HT2C receptor subtypes[1][2][3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ziprasidone (20 mg/kg; p.o.; daily for 7 weeks) gains significantly less weight, has a lower level of physical activity, showed a higher resting energy expenditure, and displays a greater capacity for thermogenesis when subjected to cold[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old female Sprague-Dawley rats weighing 200 to 250 g[4]
Dosage: 20 mg/kg
Administration: P.o.; daily for 7 weeks
Result: Gained significantly less weight, had a lower level of physical activity, showed a higher resting energy expenditure, and displayed a greater capacity for thermogenesis when subjected to cold.
Clinical Trial
Molecular Weight

449.40

Formula

C₂₁H₂₂Cl₂N₄OS

CAS No.

122883-93-6

SMILES

ClC1=CC2=C(CC(N2)=O)C=C1CCN(CC3)CCN3C4=NSC5=C4C=CC=C5.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ZiprasidoneCP-88059CP88059CP 880595-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorneuronaluptakeantipsychoticSprague-DawleyratsnorepinephrineInhibitorinhibitorinhibit

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Product Name:
Ziprasidone hydrochloride
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HY-14542A
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