1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor
  3. Ziprasidone

Ziprasidone  (Synonyms: CP-88059)

Cat. No.: HY-14542 Purity: 98.28%
COA Handling Instructions

Ziprasidone (CP-88059), an orally active antipsychotic agent, is a combined 5-HT and dopamine receptor antagonist. Ziprasidone mesylate trihydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM).

For research use only. We do not sell to patients.

Ziprasidone Chemical Structure

Ziprasidone Chemical Structure

CAS No. : 146939-27-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 87 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 87 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 79 In-stock
Estimated Time of Arrival: December 31
50 mg USD 198 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Ziprasidone

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ziprasidone (CP-88059), an orally active antipsychotic agent, is a combined 5-HT and dopamine receptor antagonist[1]. Ziprasidone mesylate trihydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM)[1].

IC50 & Target[1][2]

Rat 5-HT1A Receptor

3.4 nM (Ki)

human 5-HT1A Receptor

2.5 nM (Ki)

Rat D2 Receptor

4.8 nM (Ki)

Rat 5-HT2A

0.42 nM (Ki)

In Vitro

Ziprasidone (0-500 nM, 150 seconds) blocks wild-type hERG current[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: HEK-293 cells
Concentration: 0-500 nM
Incubation Time: 150 seconds
Result: Blocked wild-type hERG current in a voltage- and concentration-dependent manner (IC50 = 120 nm).
In Vivo

Ziprasidone (oral gavage; 20 mg/kg; once daily; 7 weeks) results in weight loss, low level physical activity, high resting energy expenditure and greater capacity for thermogenesis when subjected to cold[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old female Sprague-Dawley rats weighing 200 to 250 g[3]
Dosage: 20 mg/kg
Administration: Oral gavage; 20 mg/kg; once daily; 7 weeks
Result: Gained significantly less weight (P = 0.031), had a lower level of physical activity (P = 0.016), showed a higher resting energy expenditure (P < 0.001), and displayed a greater capacity for thermogenesis when subjected to cold (P < 0.001).
Clinical Trial
Molecular Weight

412.94

Formula

C21H21ClN4OS

CAS No.
SMILES

ClC1=CC2=C(CC(N2)=O)C=C1CCN(CC3)CCN3C4=NSC5=C4C=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 13.5 mg/mL (32.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4217 mL 12.1083 mL 24.2166 mL
5 mM 0.4843 mL 2.4217 mL 4.8433 mL
10 mM 0.2422 mL 1.2108 mL 2.4217 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.35 mg/mL (3.27 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.35 mg/mL (3.27 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.35 mg/mL (3.27 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Ziprasidone
Cat. No.:
HY-14542
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