Ziprasidone mesylate trihydrate
Based on 5 publication(s) in Google Scholar
Ziprasidone (CP-88059) mesylate trihydrate is an orally active combined 5-HT and dopamine receptor antagonist. Ziprasidone mesylate trihydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM).
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- CAS No.: 199191-69-0
- 화학식: C22H31ClN4O7S2
- 분자량:563.09
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Other In-stock Forms of Ziprasidone mesylate trihydrate
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ziprasidone mesylate trihydrate
MoreAll 5-HT Receptor Isoforms
MoreAll Dopamine Receptor Isoforms
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Biological Activity
제품 설명
IC50 & Target
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5-HT2A Receptor |
Rat D2 Receptor 4.8 nM (Ki) |
Rat 5-HT2 Receptor 0.42 nM (Ki) |
Rat 5-HT1A Receptor 3.4 nM (Ki) |
5-HT1A Receptor |
In Vitro
Ziprasidone mesylate trihydrate (0-500 nM, 150 seconds) blocks wild-type hERG current[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK-293 cells[2]
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Concentration:0-500 nM
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Incubation Time:150 seconds
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Result:Blocked wild-type hERG current in a voltage- and concentration-dependent manner (IC50 = 120 nm).
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eight-week-old female Sprague-Dawley rats weighing 200 to 250 g[3]
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Dosage:20 mg/kg
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Administration:Oral gavage; 20 mg/kg; once daily; 7 weeks
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Result:Gained significantly less weight (P = 0.031), had a lower level of physical activity (P = 0.016), showed a higher resting energy expenditure (P < 0.001), and displayed a greater capacity for thermogenesis when subjected to cold (P < 0.001).
Chemical Information
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CAS No. 199191-69-0
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분자량 563.09
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화학식 C22H31ClN4O7S2
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SMILES
O=S(C)(O)=O.ClC1=CC2=C(CC(N2)=O)C=C1CCN(CC3)CCN3C4=NSC5=C4C=CC=C5.O.O.O
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Synonyms
CP-88059 mesylate trihydrate
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
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Drug Test Anal
Supramolecular Solvent Extraction for Doping Control Analysis of Prohibited Substances in Horse Urine. [Abstract]2026 May;18(5):652-668. PMID: 41814125 -
bioRxiv
A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG. [Abstract]2026 Apr 18:2026.04.17.719256. PMID: 42039650 -
순도&문서
References
[1]. H Rollema, et al. 5-HT(1A) receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex. Biol Psychiatry. 2000 Aug 1;48(3):229-37. [Content Brief]
[2]. Zhi Su, et al. Block of hERG channel by ziprasidone: biophysical properties and molecular determinants. Biochem Pharmacol. 2006 Jan 12;71(3):278-86. [Content Brief]
[3]. Subin Park, et al. The effect of ziprasidone on body weight and energy expenditure in female rats. Metabolism. 2012 Jun;61(6):787-93. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ziprasidone mesylate trihydrate Related Classifications
HY-14542B Related Classifications
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