1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Mexiletine hydrochloride

Mexiletine hydrochloride (Synonyms: KOE-1173 hydrochloride)

Cat. No.: HY-A0093 Purity: 98.83%
Handling Instructions

Mexiletine hydrochloride (KOE-1173 hydrochloride), a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker.

For research use only. We do not sell to patients.

Mexiletine hydrochloride Chemical Structure

Mexiletine hydrochloride Chemical Structure

CAS No. : 5370-01-4

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 84 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Mexiletine hydrochloride (KOE-1173 hydrochloride), a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker[1][2].

Clinical Trial
Molecular Weight

215.72

Formula

C₁₁H₁₈ClNO

CAS No.
SMILES

CC(N)COC1=C(C)C=CC=C1C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 41 mg/mL (190.06 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6356 mL 23.1782 mL 46.3564 mL
5 mM 0.9271 mL 4.6356 mL 9.2713 mL
10 mM 0.4636 mL 2.3178 mL 4.6356 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MexiletineKOE-1173KOE1173KOE 1173Sodium ChannelNa channelsNa+ channelsantiarrhythmicClass IBmyocardialischemiaInhibitorinhibitorinhibit

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Product Name:
Mexiletine hydrochloride
Cat. No.:
HY-A0093
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