Mepivacaine hydrochloride

Cat. No.: HY-B0517A Purity: 99.83%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.

For research use only. We do not sell to patients.

Mepivacaine hydrochloride Chemical Structure

CAS No. : 1722-62-9

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 88	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 88	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
1 g	USD 132	In-stock	Estimated Time of Arrival: December 31
5 g	USD 396	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Mepivacaine hydrochloride:

(+)-Mepivacaine In-stock
Mepivacaine In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization^[1]^[2].

In Vitro

Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action^[2].
Mepivacaine hydrochloride has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine)^[3].
Mepivacaine hydrochloride displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

282.81

Formula

C₁₅H₂₃ClN₂O

CAS No.

1722-62-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(CCCC1)N1C)NC(C(C)=CC=C2)=C2C.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (353.59 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5359 mL	17.6797 mL	35.3594 mL
5 mM	0.7072 mL	3.5359 mL	7.0719 mL
10 mM	0.3536 mL	1.7680 mL	3.5359 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (353.59 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.83%

Select Batch:

Data Sheet (275 KB) SDS (420 KB)

COA (252 KB) LCMS (262 KB)

Handling Instructions (2659 KB)

References

[1]. Froehle M, et al. ECMO for Cardiac Rescue after Accidental Intravenous Mepivacaine Application. Case Rep Pediatr. 2012;2012:491692. [Content Brief]

[2]. mepivacaine hydrochloride.

[3]. Burm, A.G., et al., Pharmacokinetics of the enantiomers of mepivacaine after intravenous administration of the racemate in volunteers. Anesth Analg, 1997. 84(1): p. 85-9. [Content Brief]

[4]. Leffler, A., J. Reckzeh, and C. Nau, Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites. Eur J Pharmacol, 2010. 630(1-3): p. 19-28. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.5359 mL	17.6797 mL	35.3594 mL	88.3986 mL
	5 mM	0.7072 mL	3.5359 mL	7.0719 mL	17.6797 mL
	10 mM	0.3536 mL	1.7680 mL	3.5359 mL	8.8399 mL
	15 mM	0.2357 mL	1.1786 mL	2.3573 mL	5.8932 mL
	20 mM	0.1768 mL	0.8840 mL	1.7680 mL	4.4199 mL
	25 mM	0.1414 mL	0.7072 mL	1.4144 mL	3.5359 mL
	30 mM	0.1179 mL	0.5893 mL	1.1786 mL	2.9466 mL
	40 mM	0.0884 mL	0.4420 mL	0.8840 mL	2.2100 mL
	50 mM	0.0707 mL	0.3536 mL	0.7072 mL	1.7680 mL
	60 mM	0.0589 mL	0.2947 mL	0.5893 mL	1.4733 mL
	80 mM	0.0442 mL	0.2210 mL	0.4420 mL	1.1050 mL
	100 mM	0.0354 mL	0.1768 mL	0.3536 mL	0.8840 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.