Mepivacaine-d3
Based on 1 Customer Validation
Mepivacaine-d3 is the deuterium labeled Mepivacaine. Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 1346597-90-7
- Formula: C15H19D3N2O
- Molecular Weight:249.37
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1346597-90-7
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Unlabeled Cas 1722-62-9
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Appearance Solid
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Molecular Weight 249.37
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Formula C15H19D3N2O
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Color White to off-white
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SMILES
O=C(C1N(CCCC1)C([2H])([2H])[2H])NC2=C(C=CC=C2C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMF : ≥ 30 mg/mL (120.30 mM)
Ethanol : ≥ 30 mg/mL (120.30 mM)
DMSO : ≥ 25 mg/mL (100.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Froehle M, et al. ECMO for Cardiac Rescue after Accidental Intravenous Mepivacaine Application. Case Rep Pediatr. 2012;2012:491692. [Content Brief]
[3]. mepivacaine hydrochloride.
[4]. Burm, A.G., et al., Pharmacokinetics of the enantiomers of mepivacaine after intravenous administration of the racemate in volunteers. Anesth Analg, 1997. 84(1): p. 85-9. [Content Brief]
[5]. Leffler, A., J. Reckzeh, and C. Nau, Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites. Eur J Pharmacol, 2010. 630(1-3): p. 19-28. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / DMF / Ethanol | 1 mM | 4.0101 mL | 20.0505 mL | 40.1011 mL | 100.2526 mL |
| 5 mM | 0.8020 mL | 4.0101 mL | 8.0202 mL | 20.0505 mL | |
| 10 mM | 0.4010 mL | 2.0051 mL | 4.0101 mL | 10.0253 mL | |
| 15 mM | 0.2673 mL | 1.3367 mL | 2.6734 mL | 6.6835 mL | |
| 20 mM | 0.2005 mL | 1.0025 mL | 2.0051 mL | 5.0126 mL | |
| 25 mM | 0.1604 mL | 0.8020 mL | 1.6040 mL | 4.0101 mL | |
| 30 mM | 0.1337 mL | 0.6684 mL | 1.3367 mL | 3.3418 mL | |
| 40 mM | 0.1003 mL | 0.5013 mL | 1.0025 mL | 2.5063 mL | |
| 50 mM | 0.0802 mL | 0.4010 mL | 0.8020 mL | 2.0051 mL | |
| 60 mM | 0.0668 mL | 0.3342 mL | 0.6684 mL | 1.6709 mL | |
| 80 mM | 0.0501 mL | 0.2506 mL | 0.5013 mL | 1.2532 mL | |
| 100 mM | 0.0401 mL | 0.2005 mL | 0.4010 mL | 1.0025 mL |
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