1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Mepivacaine

Mepivacaine 

Cat. No.: HY-B0517 Purity: >98.0%
Handling Instructions

Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.

For research use only. We do not sell to patients.

Mepivacaine Chemical Structure

Mepivacaine Chemical Structure

CAS No. : 96-88-8

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500 mg USD 80 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization[1][2].

In Vitro

Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action[2].
Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine)[3].
Mepivacaine displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels[4].

Molecular Weight

246.35

Formula

C₁₅H₂₂N₂O

CAS No.

96-88-8

SMILES

O=C(C(CCCC1)N1C)NC(C(C)=CC=C2)=C2C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature

*In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature)

Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (135.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0593 mL 20.2963 mL 40.5927 mL
5 mM 0.8119 mL 4.0593 mL 8.1185 mL
10 mM 0.4059 mL 2.0296 mL 4.0593 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

MepivacaineSodium ChannelNa channelsNa+ channelsamide-typelocalanestheticneuronalcelldepolarizationInhibitorinhibitorinhibit

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Mepivacaine
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HY-B0517
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