2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Mepivacaine

Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.

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Mepivacaine Chemical Structure

Mepivacaine Chemical Structure

CAS No. : 96-88-8

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Based on 1 publication(s) in Google Scholar

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Mepivacaine Related Antibodies

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Description

Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization[1][2].

In Vitro

Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action[2].
Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine)[3].
Mepivacaine displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mepivacaine Related Antibodies
Clinical Trial
Molecular Weight

246.35

Formula

C15H22N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(CCCC1)N1C)NC(C(C)=CC=C2)=C2C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (135.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0593 mL 20.2963 mL 40.5927 mL
5 mM 0.8119 mL 4.0593 mL 8.1185 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.10%

COA (251 KB) HNMR (263 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0593 mL 20.2963 mL 40.5927 mL 101.4816 mL
5 mM 0.8119 mL 4.0593 mL 8.1185 mL 20.2963 mL
10 mM 0.4059 mL 2.0296 mL 4.0593 mL 10.1482 mL
15 mM 0.2706 mL 1.3531 mL 2.7062 mL 6.7654 mL
20 mM 0.2030 mL 1.0148 mL 2.0296 mL 5.0741 mL
25 mM 0.1624 mL 0.8119 mL 1.6237 mL 4.0593 mL
30 mM 0.1353 mL 0.6765 mL 1.3531 mL 3.3827 mL
40 mM 0.1015 mL 0.5074 mL 1.0148 mL 2.5370 mL
50 mM 0.0812 mL 0.4059 mL 0.8119 mL 2.0296 mL
60 mM 0.0677 mL 0.3383 mL 0.6765 mL 1.6914 mL
80 mM 0.0507 mL 0.2537 mL 0.5074 mL 1.2685 mL
100 mM 0.0406 mL 0.2030 mL 0.4059 mL 1.0148 mL
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Mepivacaine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mepivacaine96-88-8Sodium ChannelNa channelsNa+ channelsamide-typelocalanestheticneuronalcelldepolarizationInhibitorinhibitorinhibit

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