1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Dofetilide

Dofetilide (Synonyms: UK 68789)

Cat. No.: HY-B0232 Purity: 98.77%
Handling Instructions

Dofetilide(Tikosyn) is a class III antiarrhythmic agent.

For research use only. We do not sell to patients.

Dofetilide Chemical Structure

Dofetilide Chemical Structure

CAS No. : 115256-11-6

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 265 In-stock
Estimated Time of Arrival: December 31
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Description

Dofetilide(Tikosyn) is a class III antiarrhythmic agent. Target: Potassium Channel In patients with congestive heart failure and reduced left ventricular function, dofetilide was effective in converting atrial fibrillation, preventing its recurrence, and reducing the risk of hospitalization for worsening heart failure. Dofetilide had no effect on mortality [1]. dofetilide preferentially blocks open (or activated) channels and that the fast inactivation may competitively slow the binding kinetics. Dofetilide acts as a slow-onset/slow-offset open channel blocker of this current at nanomolar concentrations [2].

Clinical Trial
Molecular Weight

441.56

Formula

C₁₉H₂₇N₃O₅S₂

CAS No.

115256-11-6

SMILES

CS(=O)(NC1=CC=C(CCN(C)CCOC2=CC=C(NS(=O)(C)=O)C=C2)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (226.47 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2647 mL 11.3235 mL 22.6470 mL
5 mM 0.4529 mL 2.2647 mL 4.5294 mL
10 mM 0.2265 mL 1.1323 mL 2.2647 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.77%

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Keywords:

DofetilideUK 68789UK68789UK-68789Potassium ChannelKcsAInhibitorinhibitorinhibit

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