1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Dofetilide

Dofetilide (Synonyms: UK 68789)

Cat. No.: HY-B0232 Purity: 98.39%
Handling Instructions

Dofetilide (UK 68789), as a class III antiarrhythmic agent, is an orally active, potent and specific IKr blocker. Dofetilide can be used for the research of cardiovascular disease.

For research use only. We do not sell to patients.

Dofetilide Chemical Structure

Dofetilide Chemical Structure

CAS No. : 115256-11-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 265 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Dofetilide:

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Description

Dofetilide (UK 68789), as a class III antiarrhythmic agent, is an orally active, potent and specific IKr blocker. Dofetilide can be used for the research of cardiovascular disease[1][2].

IC50 & Target

IKr[1]

In Vivo

Dofetilide (3~100 μg/kg; i.v.) increases repolarisation time via a selective prolongation of activation repolarisation interval, activation time being unchanged[2].
Dofetilide is metabolized by CYP3A4 to a mixture of inactive polar metabolites that are then excreted by the kidney[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult beagle dogs (13-15 kg)[2]
Dosage: 3~100 μg/kg
Administration: I.v.
Result: Increased repolarisation time via a selective prolongation of activation repolarisation interval, activation time being unchanged.
Clinical Trial
Molecular Weight

441.56

Formula

C₁₉H₂₇N₃O₅S₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (226.47 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2647 mL 11.3235 mL 22.6470 mL
5 mM 0.4529 mL 2.2647 mL 4.5294 mL
10 mM 0.2265 mL 1.1323 mL 2.2647 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.39%

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Dofetilide
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HY-B0232
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