2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. E-4031

E-4031 is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies.

For research use only. We do not sell to patients.

E-4031 Chemical Structure

E-4031 Chemical Structure

CAS No. : 113559-13-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 85 In-stock
Solution
10 mM * 1 mL in Water USD 85 In-stock
Solid
5 mg USD 77 In-stock
10 mg USD 130 In-stock
50 mg USD 568 In-stock
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200 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

E-4031 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

E-4031 is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies[1].

In Vitro

E-4031 (0.1-10 μM) significantly depolarises the maximum diastolic potential (MDP) and prolongs the action charge that depolarises MDP from -58.8+0.9 to -24.5±1.8 mV at 1 μM and from -58.2±2.1 to -19.6±1.8 mV at 10 μM in single SAN cells of New Zealand albinc rabbits[2].
? E-4031 (0.1-10 μM) can block part of the outward current during the depolarisation step as well as the tail current (ITD) during subsequent repolarization in a dose-dependent manner, and depresses ITD by 88 % at 10 μM in single SAN cells of New Zealand albinc rabbits[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

E-4031 Related Antibodies
Molecular Weight

474.44

Formula

C21H29Cl2N3O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CS(=O)(NC1=CC=C(C(C2CCN(CCC3=NC(C)=CC=C3)CC2)=O)C=C1)=O.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (105.39 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1077 mL 10.5387 mL 21.0775 mL
5 mM 0.4215 mL 2.1077 mL 4.2155 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (210.77 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.1077 mL 10.5387 mL 21.0775 mL 52.6937 mL
5 mM 0.4215 mL 2.1077 mL 4.2155 mL 10.5387 mL
10 mM 0.2108 mL 1.0539 mL 2.1077 mL 5.2694 mL
15 mM 0.1405 mL 0.7026 mL 1.4052 mL 3.5129 mL
20 mM 0.1054 mL 0.5269 mL 1.0539 mL 2.6347 mL
25 mM 0.0843 mL 0.4215 mL 0.8431 mL 2.1077 mL
30 mM 0.0703 mL 0.3513 mL 0.7026 mL 1.7565 mL
40 mM 0.0527 mL 0.2635 mL 0.5269 mL 1.3173 mL
50 mM 0.0422 mL 0.2108 mL 0.4215 mL 1.0539 mL
60 mM 0.0351 mL 0.1756 mL 0.3513 mL 0.8782 mL
80 mM 0.0263 mL 0.1317 mL 0.2635 mL 0.6587 mL
100 mM 0.0211 mL 0.1054 mL 0.2108 mL 0.5269 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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E-4031 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E-4031113559-13-0E4031E 4031Potassium ChannelKcsAhERGpotassium channelanti-arrhythmicInhibitorinhibitorinhibit

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