1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. Calcium Channel
    P-glycoprotein
    Cytochrome P450
  3. Verapamil

Verapamil (Synonyms: (±)-Verapamil; CP-16533-1)

Cat. No.: HY-14275
Handling Instructions

Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research.

For research use only. We do not sell to patients.

Verapamil Chemical Structure

Verapamil Chemical Structure

CAS No. : 52-53-9

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Description

Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].

IC50 & Target

Calcium channel[1]
Permeability-glycoprotein (P-gp)[1]
CYP3A4[1]

In Vitro

The EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells is inhibited by cationic drugs, and inhibits by verapamil in a concentration-dependent manner with an IC50 of 98.0 μM[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Given orally Verapamil is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation[2].
Verapamil is injected i.v. into a femoral vein prior to ischemia. Verapamil (1 mg/kg) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Total arrhythmia scores are significantly increased when the heart is subjected to ischemia. Verapamil (1 mg/kg) significantly prevents the enhancement of total arrhythmia scores induced by ischemia[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

454.60

Formula

C₂₇H₃₈N₂O₄

CAS No.

52-53-9

SMILES

COC1=CC=C(C(C#N)(C(C)C)CCCN(CCC2=CC=C(OC)C(OC)=C2)C)C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Verapamil(±)-Verapamil CP-16533-1Calcium ChannelP-glycoproteinCytochrome P450Ca2+ channelsCa channelsP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243CYPsCYP3A4PalbociclibantiarrhythmichighbloodpressureanginalysosomotropicInhibitorinhibitorinhibit

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Verapamil
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HY-14275
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