1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. Calcium Channel
    P-glycoprotein
    Cytochrome P450
  3. Verapamil

Verapamil (Synonyms: (±)-Verapamil; CP-16533-1)

Cat. No.: HY-14275
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Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina treatment.

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Verapamil Chemical Structure

Verapamil Chemical Structure

CAS No. : 52-53-9

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Description

Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina treatment[1][2][3].

IC50 & Target

Calcium channel[1]
Permeability-glycoprotein (P-gp)[1]
CYP3A4[1]

In Vitro

The EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells is inhibited by cationic drugs, and inhibits by verapamil in a concentration-dependent manner with an IC50 of 98.0 μM[4].

In Vivo

Intravenous Verapamil is highly effective in the termination of paroxysmal reciprocating atrioventricular tachycardia, whether associated with preexcitation or involving the atrioventricular node alone[2].
Given orally it is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation[2].

Molecular Weight

454.60

Formula

C₂₇H₃₈N₂O₄

CAS No.

52-53-9

SMILES

COC1=CC=C(C(C#N)(C(C)C)CCCN(CCC2=CC=C(OC)C(OC)=C2)C)C=C1OC

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Keywords:

Verapamil(±)-VerapamilCP-16533-1Calcium ChannelP-glycoproteinCytochrome P450Ca2+ channelsCa channelsP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243CYPsCYP3A4PalbociclibantiarrhythmichighbloodpressureanginalysosomotropicInhibitorinhibitorinhibit

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Verapamil
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