Role of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes

  • Antimicrob Agents Chemother. 2007 Aug;51(8):3030-2. doi: 10.1128/AAC.00404-07.
Adriano C Coelho  1 ,  Nadine Messier ,  Marc Ouellette ,  Paulo C Cotrim
Affiliations
  • 1. Instituto de Medicina Tropical, Universidade de São Paulo, Av Dr Enéas de Carvalho Aguiar, 470, 4 andar, São Paulo, Brazil.
PMID: 17452480 DOI: 10.1128/AAC.00404-07
Abstract

Pentamidine is a second-line agent in the treatment of leishmaniasis whose mode of action and resistance mechanism are not well understood. In this work, we show that the intracellular ABC protein PRP1 (pentamidine resistance protein 1) (ABCC7) can confer resistance to pentamidine in Leishmania sp. parasites in the intracellular stage.