Multidrug resistance reversal activity of key ningalin analogues

  • Bioorg Med Chem Lett. 2003 May 19;13(10):1777-81. doi: 10.1016/s0960-894x(03)00294-4.
Danielle R Soenen  1 ,  Inkyu Hwang ,  Michael P Hedrick ,  Dale L Boger
Affiliations
  • 1. The Scripps Research Institute and the Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
PMID: 12729663 DOI: 10.1016/s0960-894x(03)00294-4
Abstract

Key analogue derivatives of the ningalins, potent multidrug resistance (MDR) reversal compounds, were examined resulting in the discovery of a potent MDR reversal agent that hypersensitizes P-gp resistant tumor cell lines to front-line conventional therapeutic agents.