Cytochrome P450 Inhibitors

CYP1

CYP2

CYP3

CYP4

CYP11

CYP17

CYP19

CYP26

CYP51

Cytochrome P450 Inducers, Inhibitors & Activators

Product Name	CYP1	CYP2	CYP3	CYP4	CYP11	CYP17	CYP19	CYP26	CYP51	Purity
Apigenin		CYP2								99.58%
Ketoconazole			CYP3	CYP4						99.86%
Antitumor agent-88	CYP1A1, Ki: 1.4 μM
Cobicistat			CYP3							99.77%
Abiraterone acetate						CYP17				99.96%
Letrozole							Aromatase			99.92%
Fenofibrate		CYP2C19, IC₅₀: 0.2 μM CYP2B6, IC₅₀: 0.7 μM CYP2C9, IC₅₀: 9.7 μM CYP2C8, IC₅₀: 4.8 μM	CYP3A4, IC₅₀: 142.1 μM							99.99%
Clarithromycin			CYP3							≥98.0%
Endoxifen hydrochloride							Aromatase			98.20%
BMS-986202		CYP2C19, IC₅₀: 14 μM								99.92%
Atazanavir sulfate			CYP3							99.94%
Anastrozole							Aromatase			99.99%
Isavuconazole			CYP3							99.99%
Salvianolic acid C		CYP2C8, Ki: 4.82 μM CYP2J2, Ki: 5.75 μM								99.94%
Talarozole								CYP26		99.61%
Exemestane							Aromatase			99.92%
HET0016				CYP4						99.77%
Mefentrifluconazole									CYP51A, Kd: 0.5 nM	99.61%
Troleandomycin			CYP3							≥98.0%
Gemfibrozil	CYP1A2, Ki: 82 μM	CYP2C9, Ki: 5.8 μM CYP2C19, Ki: 24 μM CYP2C8, Ki: 69 μM								99.91%
Galangin	CYP1									99.96%
Ginsenoside Rd	CYP1A2, IC₅₀: 78.4 μM	CYP2D6, IC₅₀: 58 μM CYP2C9, IC₅₀: 85.1 μM	CYP3A4, IC₅₀: 81.7 μM							98.02%
AZD7325	CYP1A2		CYP3A4							99.27%
Olivetol		CYP2								99.81%
K777			CYP3							99.60%
Casopitant mesylate			CYP3A4							99.84%
Bergamottin	CYP1A1, Ki: 10.703 nM CYP1A1, IC₅₀: 0.192 μM CYP1A2, IC₅₀: 5.077 μM	CYP2B2, IC₅₀: 4.535 μM CYP2B1, IC₅₀: 9.495 μM								99.80%
Rhapontigenin	CYP1A1, IC₅₀: 400 nM									99.66%
Clopidogrel hydrogen sulfate		CYP2B6, IC₅₀: 18.2 nM CYP2C19, IC₅₀: 524 nM								99.75%
Alpha-Naphthoflavone							Aromatase			98.35%
Gemfibrozil 1-O-β-glucuronide		CYP2C8, IC₅₀: 4.07 μM								99.88%
Cecropin B			CYP3							98.07%
AS1810722			CYP3A4							98.56%
Clobetasol propionate			CYP3A5, IC₅₀: 0.206 μM CYP3A4, IC₅₀: 15.6 μM							99.85%
Tetrahydrocurcumin		CYP2C9	CYP3A4							99.43%
Ginsenoside C-K		CYP2C9, IC₅₀: 32 μM CYP2A6, IC₅₀: 63.6 μM								98.04%
(S)-Mephenytoin		CYP2								99.81%
Ezutromid	CYP1
Fadrozole hydrochloride							Aromatase			99.22%
Oxiconazole nitrate			CYP3A4 CYP3							≥98.0%
Fadrozole							Aromatase			99.69%
Curcumenol			CYP3							99.69%
Oteseconazole									CYP51	99.56%
TMS	CYP1B1, IC₅₀: 6 nM CYP1A1, IC₅₀: 300 nM CYP1A2, IC₅₀: 3.1 μM CYP1B1, Ki: 3 nM									99.21%
Fomepizole		CYP2E1								99.67%
APD668		CYP2C9, Ki: 0.1 μM								99.10%
Cedrol		CYP2	CYP3							≥98.0%
Liarozole								CYP26, IC₅₀: 7 μM		98.52%
2-Phenyl-2-(1-piperidinyl)propane	CYP1A2, IC₅₀: >300 μM	CYP2B6, IC₅₀: 5.1 μM CYP2B6, Ki: 5.6 μM CYP2D6, IC₅₀: 74 μM CYP2A6, IC₅₀: >300 μM CYP2C8, IC₅₀: >300 μM CYP2C9, EC₅₀: >300 μM CYP2C19, IC₅₀: >300 μM CYP2E1, IC₅₀: >300 μM	CYP3A, IC₅₀: 200 μM							99.81%
ACP-5862		CYP2C8	CYP3A4							98.09%
Orteronel						CYP17				99.70%
Tebuconazole									CYP51	99.66%
Dagrocorat		CYP2D6	CYP3A							99.90%
AMG-208			CYP3A4, IC₅₀: 32 μM							99.86%
Dapaconazole								CYP26, IC₅₀: 1.4 μM		98.95%
5,7-Dimethoxyflavone			CYP3A							99.86%
Gentiopicroside		CYP2								99.52%
CYP3cide			CYP3A4, EC₅₀: 30 nM CYP3A5, EC₅₀: 17 μM CYP3A7, EC₅₀: 71 μM							99.46%
Phillyrin	CYP1	CYP2								98.99%
Fipronil	CYP1	CYP2	CYP3							≥98.0%
Atazanavir			CYP3
PC945									CYP51A, IC₅₀: 0.23 μM CYP51B, IC₅₀: 0.22 μM	99.62%
Endoxifen							Aromatase
DMU2105	CYP1B1, IC₅₀: 10 nM CYP1A1, IC₅₀: 742 nM									99.61%
DMU2139	CYP1B1, IC₅₀: 9 nM CYP1A1, IC₅₀: 795 nM									≥98.0%
Pradefovir mesylate			CYP3							99.89%
Tetrahydropiperine	CYP1A1, IC₅₀: 23 μM									99.45%
α-Terpinyl acetate		CYP2B6, Kd: 5.4  μM
N-Nornuciferine		CYP2								99.82%
Dihydrolanosterol									CYP51
Oleuropein							Aromatase			99.05%
MCH-1 antagonist 1			CYP3A4, IC₅₀: 10 μM
Linderane		CYP2								98.86%
CYP4A11/CYP4F2-IN-2				CYP4A11, IC₅₀: 140 nM CYP4F2, IC₅₀: 40 nM						98.69%
1'-Hydroxy bufuralol		CYP2
Eriodictyol chalcone							Aromatase
LKY-047		CYP2J2, IC₅₀: 1.7 μM								98.85%
ε-Viniferin	CYP1A2, Ki: 5 μM ((EROD))	CYP2B6, Ki: 3 μM ((BROD)) CYP2A6, Ki: 60 μM ((COH)) CYP2E1, IC₅₀: 25 μM ((CHZ))	CYP3A4, Ki: 10 μM ((TST))	CYP4A, IC₅₀: 15 μM ((LwOH))						≥98.0%
Mephenytoin		CYP2								99.96%
7-Ethoxyresorufin	CYP1									98.96%
Revexepride			CYP3A4							99.84%
Liarozole dihydrochloride								CYP26, IC₅₀: 7 μM		≥99.0%
Ticlopidine		CYP2	CYP3							99.34%
Friedelin		CYP2	CYP3							≥99.0%
Obtusifoliol									CYP51	≥99.0%
Chrysosplenetin			CYP3A CYP3							99.75%
Isosilybin			CYP3							99.82%
Harmalol hydrochloride	CYP1									99.72%
Flavanone							Aromatase			99.84%
β-Apo-8'-carotenal	CYP1A1 CYP1A2
Seviteronel (R enantiomer)						CYP17				99.46%
Schisandrin A			CYP3A, IC₅₀: 6.6 μM							99.43%
Schisandrol B		CYP2	CYP3A							99.57%
Ginsenoside F1		CYP2	CYP3A4 CYP3							≥99.0%
2,6-Dimethylquinoline	CYP1A2, IC₅₀: 3.3 μM	CYP2B6, IC₅₀: 480 μM								98.19%
Carbosulfan	CYP1	CYP2	CYP3							≥98.0%
Abiraterone decanoate						CYP17
BI 653048	CYP1A2, IC₅₀: 50 μM	CYP2D6, IC₅₀: 41 μM CYP2C9, IC₅₀: 12 μM CYP2C19, IC₅₀: 9 μM	CYP3A4, IC₅₀: 8 μM
IHMT-PI3Kδ-372		CYP2C9, IC₅₀: 2.7 μM								99.75%
Fomepizole hydrochloride		CYP2E1
BMS-819881			CYP3A4, EC₅₀: 13 μM
BMS-986339		CYP2C8, IC₅₀: 8 μM CYP2C9, IC₅₀: 13.5 μM
Fadrozole hydrochloride hemihydrate							Aromatase
Anastrozole-d₁₂							Aromatase
Endoxifen-d₅							Aromatase
CYP3A4-IN-2			CYP3A4, IC₅₀: 0.055 μM
Phortress	CYP1									99.25%
CYP11B1-IN-2	CYP1A2, IC₅₀: >10 μM	CYP2C9, IC₅₀: >10 μM CYP2C19, IC₅₀: >10 μM CYP2D6, IC₅₀: >10 μM CYP2E1, IC₅₀: >10 μM	CYP3A4, IC₅₀: >10 μM		CYP11B1, IC₅₀: 9 ± 2 nM (human CYP11B1) CYP11B1, IC₅₀: 25 nM (rat CYP11B1) CYP11B2, IC₅₀: 1121 ± 237 nM
SYN20028567							Aromatase
CYP4Z1-IN-1		CYP2D6, IC₅₀: >10 000 nM CYP2C9, IC₅₀: >10 000 nM	CYP3A4, IC₅₀: >10 000 nM	CYP4Z1, IC₅₀: 41.8 ± 1.4 nM CYP4F11, IC₅₀: 291.3 ± 46 nM CYP4F12, IC₅₀: 1598.3 ± 5 nM
ML252	CYP1A2, IC₅₀: 6.1 μM	CYP2C9, IC₅₀: 18.9 μM CYP2D6, IC₅₀: 19.9 μM	CYP3A4, IC₅₀: 3.9 μM
CYP3A4-IN-3			CYP3A4, IC₅₀: 0.075 μM
Quilseconazole									CYP51
CYP1B1-IN-2	CYP1B1, IC₅₀: 0.52 nM CYP1A1, IC₅₀: 16.7 nM CYP1A2, IC₅₀: 94.2 nM
CYP1B1-IN-5	CYP1B1, IC₅₀: 4.7 nM CYP1A1, IC₅₀: 190.7 nM CYP1A2, IC₅₀: 585.7 nM
FGFR-IN-10		CYP2C9, IC₅₀: 3.33 μM CYP2C19, IC₅₀: 18.75 μM CYP2D6, IC₅₀: 4.34 μM	CYP3A4, IC₅₀: 0.69 μM
Nonsteroidal aromatase inhibitor 1							Aromatase
Antihistamine-1		CYP2D6, IC₅₀: 5.4 μM								99.45%
Isolimonexic acid							Aromatase
HIV-1 inhibitor-40		CYP2C9, IC₅₀: 5.16 μM CYP2C19, IC₅₀: 4.51 μM
(R)-(+)-Aminoglutethimide							Aromatase
Letrozole-d₄							Aromatase			99.82%
Vorozole							Aromatase
Anticancer agent 78							Aromatase
CYP3A4-IN-1			CYP3A4, IC₅₀: 0.085 μM
CYP51/HDAC-IN-1									CYP51
Exemestane-¹³C₃							Aromatase
Kushenol K			CYP3A4, Ki: 1.35 μM
SDZ285428									CYP51	98.04%
CYP1B1-IN-3	CYP1B1, IC₅₀: 6.6 nM CYP1A1, IC₅₀: 347.3 nM CYP1A2, IC₅₀: >10000 nM
Antitumor agent-87	CYP1A1, Ki: 0.23 μM
DL-Acetylshikonin	CYP1A2, IC₅₀: 4.0 μM	CYP2A6, IC₅₀: 3.8 μM CYP2B6, IC₅₀: 2.0 μM CYP2C8, IC₅₀: 1.4 μM CYP2C9, IC₅₀: 3.3 μM CYP2C19, IC₅₀: 2.5 μM CYP2D6, IC₅₀: 2.5 μM CYP2E1, IC₅₀: 2.7 μM CYP2J2, IC₅₀: 3.3 μM	CYP3A, IC₅₀: 2.3 μM
Exemestane-d₂							Aromatase
5,7,2',6'-Tetrahydroxyflavone			CYP3A4, IC₅₀: 7.8 μM
Dagrocorat hydrochloride		CYP2D6	CYP3A							99.85%
7-Ethoxy-4-methylcoumarin	CYP1A1	CYP2B6 CYP2B4
CYP1B1-IN-4	CYP1B1, IC₅₀: 0.2 nM CYP1A1, IC₅₀: 3.98 μM
YM511							Aromatase
BI 653048 phosphate	CYP1A2, IC₅₀: 50 μM	CYP2D6, IC₅₀: 41 μM CYP2C9, IC₅₀: 12 μM CYP2C19, IC₅₀: 9 μM	CYP3A4, IC₅₀: 8 μM
CYP11B2-IN-1					CYP11B2, IC₅₀: 2.3 nM CYP11B1, IC₅₀: 142 nM
Exemestane-d₃							Aromatase
Nav1.7-IN-8		CYP2C9, IC₅₀: 0.17 μM	CYP3A4, IC₅₀: 0.077 μM
Oxiconazole			CYP3A4
Tetrahydrocurcumin-d₆		CYP2	CYP3
Antibacterial agent 132							Aromatase
CYP4A11/CYP4F2-IN-1				CYP4A11, IC₅₀: 19 nM CYP4F2, IC₅₀: 17 nM
MS-PPOH		CYP2								99.27%
Androsta-1,4,6-triene-3,17-dione							Aromatase
7-Hydroxyflavanone							Aromatase
Phortress free base	CYP1
Monoamine oxidase/Aromatase-IN-1							Aromatase
RO6889678			CYP3A4
Azamulin			CYP3A, IC₅₀: 0.03-0.24 μM
Aromatase-IN-2							Aromatase
Ranitidine		CYP2C19 CYP2C9
Licopyranocoumarin			CYP3A4, IC₅₀: 32 μM
SR9186			CYP3							98.06%
Methysticin	CYP1A1
4,5-Dimethoxycanthin-6-one	CYP1A2, IC₅₀: 1.7 μM CYP1A2, Ki: 2.6 μM									98.68%
Org30958							Aromatase

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