2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cytochrome P450
  5. CYP1 Isoform

CYP1

 

CYP1 Related Products (34):

Cat. No. Product Name Effect Purity
  • HY-N0382
    Galangin
    		Inhibitor 99.96%
    Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor.
  • HY-B0258
    Gemfibrozil
    		Inhibitor 99.91%
    Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering drug; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively.
  • HY-N0043
    Ginsenoside Rd
    		Inhibitor 98.02%
    Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells.
  • HY-19340
    TMS
    		Inhibitor 99.21%
    TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive CYP1B1 inhibitor with an IC50 of 6 nM and a Ki value of 3 nM.
  • HY-N2194
    Bergamottin
    		Inhibitor 99.80%
    Bergamottin is a potent and competitive CYP1A1 inhibitor with a Ki of 10.703 nM.
  • HY-148595
    Antitumor agent-88
    		Inhibitor
    Antitumor agent-88 exhibits potent antimitotic activity and arrests cell in the G2/M phase.
  • HY-18063
    ML252
    		Inhibitor
    ML252 is a selective inhibitor of potassium channel, targeting to KCNQ2 channel (Kv7.2) (IC50=69 nM).
  • HY-152196
    CYP1B1-IN-5
    		Inhibitor
    CYP1B1-IN-5 (Compound 6q) is a potent and selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC50 of 4.7 nM.
  • HY-D0145
    7-Ethoxyresorufin
    		Inhibitor 98.96%
    7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1.
  • HY-N2229
    Rhapontigenin
    		Inhibitor 99.66%
    Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities.
  • HY-N0482
    Phillyrin
    		Activator 98.82%
    Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities.
  • HY-111052
    AZD7325
    		Activator 99.27%
    AZD7325 is a potent and orally active partial selective PAM of GABAAα2 and Aα3 receptor (Ki=0.3 and 1.3 nM, respectively), and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes.
  • HY-17614
    Ezutromid
    		98.94%
    Ezutromid (SMT C1100) is a first-in-class, orally active benzoxazole utrophin modulator with an EC50 of 0.91 μM.
  • HY-W010195
    2,6-Dimethylquinoline
    		Inhibitor 98.19%
    2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a CYP1A2 inhibitor with an IC50 of 3.3 µM.
  • HY-N2625A
    Harmalol hydrochloride
    		99.72%
    Harmalol hydrochloride, a beta carboline alkaloid, presents in several medicinal plants such as Peganum harmala.
  • HY-B0822
    Fipronil
    		Activator ≥98.0%
    Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks.
  • HY-101284
    DMU2105
    		Inhibitor 99.61%
    DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively.
  • HY-B2015
    Carbosulfan
    		Inhibitor ≥98.0%
    Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers).
  • HY-N6677
    β-​Apo-​8'-​carotenal
    		Activator
    β-Apo-8'-carotenal (Apocarotenal), a provitamin A carotenoid, is an inducer of CYPlA1 and CYPlA2 in rat.
  • HY-101285
    DMU2139
    		Inhibitor ≥98.0%
    DMU2139 is a potent and specific CYP1B1 inhibitor, with IC50s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.