CYP1 Inducer
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Phortress
0 ImagesSynonyms: NSC 710305Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1.
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1,2,3,6,7,8-Hexachlorodibenzofuran
0 ImagesCat. No.: HY-W762015CAS No.: 57117-44-9Synonyms: 1,2,3,6,7,8-HxCDF1,2,3,6,7,8-Hexachlorodibenzofuran (1,2,3,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 1,2,3,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50s = 1.47 and 1.24 nM, respectively). 1,2,3,6,7,8-Hexachlorodibenzofuran reduces weight, induces thymic atrophy, and induces the expression of genes encoding the cytochrome P450 (CYP) isoform CYP1A1 and 4-chlorobiphenyl hydroxylase in rats (EC50s = 3.2, 0.9, 0.35, and 0.21 µmol/kg, respectively).
