3-Bromocarbazole-d7
Based on 1 Customer Validation
3-Bromocarbazole-d7 is the d7-labeled 3-Bromocarbazole (HY-33798). 3-Bromocarbazole is an inhibitor of the aryl hydrocarbon receptor (AHR). 3-Bromocarbazole induces the mRNA expression of CYP1A1 and CYP1B1, with EC50 values of 2500 nM and 1100 nM, respectively. 3-Bromocarbazole inhibits motor neuron axon length by downregulating the mRNA transcription levels of α1-tubulin, Gap43, Syn2a and shha in zebrafish larvae. 3-Bromocarbazole reduces central nervous system neurogenesis by downregulating the mRNA transcription levels of elavl3, nrd, mbp and gfap in zebrafish larvae. 3-Bromocarbazole induces developmental neurotoxicity and decreases body length in zebrafish larvae or embryos; at high concentrations, it also reduces hatching rate, and increases mortality and malformation rate. 3-Bromocarbazole can be used in studies related to developmental neurotoxicity and breast cancer.
For research use only. We do not sell to patients.
- Purity: 99.57%
- CAS No.: 2764814-81-3
- Formula: C12HD7BrN
- Molecular Weight:253.15
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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CYP1A1 2500 nM (EC50) |
CYP1B1 1100 nM (EC50) |
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2764814-81-3
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Unlabeled CAS 1592-95-6
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Appearance Solid
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Molecular Weight 253.15
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Formula C12HD7BrN
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Color White to off-white
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SMILES
BrC1=C([2H])C([2H])=C2NC3=C([2H])C([2H])=C([2H])C([2H])=C3C2=C1[2H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (395.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (292 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.9502 mL | 19.7511 mL | 39.5023 mL | 98.7557 mL |
| 5 mM | 0.7900 mL | 3.9502 mL | 7.9005 mL | 19.7511 mL | |
| 10 mM | 0.3950 mL | 1.9751 mL | 3.9502 mL | 9.8756 mL | |
| 15 mM | 0.2633 mL | 1.3167 mL | 2.6335 mL | 6.5837 mL | |
| 20 mM | 0.1975 mL | 0.9876 mL | 1.9751 mL | 4.9378 mL | |
| 25 mM | 0.1580 mL | 0.7900 mL | 1.5801 mL | 3.9502 mL | |
| 30 mM | 0.1317 mL | 0.6584 mL | 1.3167 mL | 3.2919 mL | |
| 40 mM | 0.0988 mL | 0.4938 mL | 0.9876 mL | 2.4689 mL | |
| 50 mM | 0.0790 mL | 0.3950 mL | 0.7900 mL | 1.9751 mL | |
| 60 mM | 0.0658 mL | 0.3292 mL | 0.6584 mL | 1.6459 mL | |
| 80 mM | 0.0494 mL | 0.2469 mL | 0.4938 mL | 1.2344 mL | |
| 100 mM | 0.0395 mL | 0.1975 mL | 0.3950 mL | 0.9876 mL |
3-Bromocarbazole-d7 Related Classifications
HY-33798S Related Classifications
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Keywords
- 3-Bromocarbazole-d7
- 2764814-81-3
- Isotope-Labeled Compounds
- Aryl Hydrocarbon Receptor
- Cytochrome P450
- Microtubule/Tubulin
- zebrafish larvae
- α1-tubulin
- shha
- Syn2a
- Gap43
- central nervous system neurogenesis
- MDA-MB-468 human breast cancer cells
- zebrafish embryos
- aryl hydrocarbon receptor
- motor neuron axon
- Inhibitor
- inhibitor
- inhibit