1592-95-6
Chemical Structure
3-Bromocarbazole
- CAS No.: 1592-95-6
- Formula:C12H8BrN
- Molecular Weight:246.11
IUPAC Name: 3-bromo-9H-carbazole
InChIKey: LTBWKAYPXIIVPC-UHFFFAOYSA-N
SMILES: BrC1=CC2=C(C=C1)NC3=C2C=CC=C3
Biological Activity: 3-Bromocarbazole is an inhibitor of the aryl hydrocarbon receptor (AHR). 3-Bromocarbazole induces the mRNA expression of CYP1A1 and CYP1B1, with EC50 values of 2500 nM and 1100 nM, respectively. 3-Bromocarbazole inhibits motor neuron axon length by downregulating the mRNA transcription levels of α1-tubulin, Gap43, Syn2a and shha in zebrafish larvae. 3-Bromocarbazole reduces central nervous system neurogenesis by downregulating the mRNA transcription levels of elavl3, nrd, mbp and gfap in zebrafish larvae. 3-Bromocarbazole induces developmental neurotoxicity and decreases body length in zebrafish larvae or embryos; at high concentrations, it also reduces hatching rate, and increases mortality and malformation rate. 3-Bromocarbazole can be used in studies related to developmental neurotoxicity and breast cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
3-Bromocarbazole | 99.70% | 3-Bromocarbazole is an inhibitor of the aryl hydrocarbon receptor (AHR). 3-Bromocarbazole induces the mRNA expression of CYP1A1 and CYP1B1, with EC50 values of 2500 nM and 1100 nM, respectively. 3-Bromocarbazole inhibits motor neuron axon length by downregulating the mRNA transcription levels of α1-tubulin, Gap43, Syn2a and shha in zebrafish larvae. 3-Bromocarbazole reduces central nervous system neurogenesis by downregulating the mRNA transcription levels of elavl3, nrd, mbp and gfap in zebrafish larvae. 3-Bromocarbazole induces developmental neurotoxicity and decreases body length in zebrafish larvae or embryos; at high concentrations, it also reduces hatching rate, and increases mortality and malformation rate. 3-Bromocarbazole can be used in studies related to developmental neurotoxicity and breast cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
3-Bromocarbazole-d7 | 99.57% | 3-Bromocarbazole-d7 is a deuterium labeled 3-Bromocarbazole (HY-33798). 3-Bromocarbazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Dong M, et al. 3-bromocarbazole-induced developmental neurotoxicity and effect mechanisms in zebrafish[J]. Acs Es&T Water, 2023, 3(8): 2471-2480.
- [2]. Riddell N, et al. Characterization and Biological Potency of Mono- to Tetra-Halogenated Carbazoles. Environmental science & technology. 2015 Sep 01;49(17):10658-66.
Keywords
