1. Neuronal Signaling
    Metabolic Enzyme/Protease
  2. Monoamine Oxidase
    Endogenous Metabolite
  3. Norharmane

Norharmane (Synonyms: Norharman; β-Carboline)

Cat. No.: HY-W008566 Purity: >97.0%
Handling Instructions

Norharmane (Norharman), isolated from coffee, is a potent and selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μM.

For research use only. We do not sell to patients.

Norharmane Chemical Structure

Norharmane Chemical Structure

CAS No. : 244-63-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
100 mg USD 55 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Norharmane (Norharman), isolated from coffee, is a potent and selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μM[1].

IC50 & Target

MAO-A

3.34 μM (Ki)

Human Endogenous Metabolite

 

Molecular Weight

168.20

Formula

C₁₁H₈N₂

CAS No.

244-63-3

SMILES

N1C2=C(C=CC=C2)C2=C1C=NC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 11 mg/mL (65.40 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9453 mL 29.7265 mL 59.4530 mL
5 mM 1.1891 mL 5.9453 mL 11.8906 mL
10 mM 0.5945 mL 2.9727 mL 5.9453 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.1 mg/mL (6.54 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 1.1 mg/mL (6.54 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

NorharmaneNorharman β-CarbolineMonoamine OxidaseEndogenous MetaboliteMAOMonoamineoxidaseCoffeeAlkaloidParkinsondiseaseNeuroprotectionInhibitorinhibitorinhibit

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Product Name:
Norharmane
Cat. No.:
HY-W008566
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