Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives

  • J Nat Prod. 2001 Jul;64(7):958-60. doi: 10.1021/np0101189.
J Ishida  1 ,  H K Wang ,  M Oyama ,  M L Cosentino ,  C Q Hu ,  K H Lee
Affiliations
  • 1. Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7360, USA.
PMID: 11473435 DOI: 10.1021/np0101189
Abstract

Matairesinol (1) and harman (5), identified from Symplocos setchuensis, were found to inhibit HIV replication in H9 lymphocyte cells. Anti-HIV evaluation of 28 derivatives of 5 revealed that compound 19 showed potent activity with EC(50) and therapeutic index values of 0.037 microM and 210, respectively.