2. Natural Products
  3. Alkaloids
  4. Pyridine Alkaloids

Pyridine Alkaloids

Pyridine Alkaloids (96):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-123033A
    Nicotinamide riboside chloride 23111-00-4 99.59%
    Nicotinamide riboside Chloride, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.
    Nicotinamide riboside chloride
  • HY-B0150
    Nicotinamide 98-92-0 99.86%
    Nicotinamide is a form of vitamin B3 or niacin that inhibits sirtuin 2 (SIRT2) activity in vitro, with an EC50 of 2 μM. Nicotinamide inhibits up to 90% melanoma cell number and increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibts tumor growth in vivo and improves survival of melanoma-bearing mice, which can be used for the research of skin cancers such as melanoma.
    Nicotinamide
  • HY-17024
    Cyclopamine 4449-51-8 99.97%
    Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.
    Cyclopamine
  • HY-N2329
    Piperlongumine 20069-09-4 99.87%
    Piperlongumine is a alkaloid, possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome.
    Piperlongumine
  • HY-N2149
    Tomatidine 77-59-8 ≥98.0%
    Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine activates autophagy either in mammal cells or C elegans.
    Tomatidine
  • HY-N11016
    1-Methoxymethyl-β-carboline 55854-60-9
    1-Methoxymethyl-β-carboline is a natural product isolated from the root of Eurycoma longifolia.
    1-Methoxymethyl-β-carboline
  • HY-N10681
    Evonimine 41758-69-4
    Evonimine (Euonine) is an alkaloid isolated from Tripterygium wilfordii Hook. Evonimine exhibits significant inhibition of humoral-mediated immunity using the haemolytic response as an indicator, and shows good anti-feeding activity against the lepidopteran Spodoptera littoralis.
    Evonimine
  • HY-W099757
    (±)-Coniine hydrochloride 15991-59-0
    (±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg.
    (±)-Coniine hydrochloride
  • HY-N0052A
    Sanguinarine chloride 5578-73-4 99.24%
    Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.
    Sanguinarine chloride
  • HY-100807
    Quinolinic acid 89-00-9 99.81%
    Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction.
    Quinolinic acid
  • HY-N0414
    Trigonelline 535-83-1 99.98%
    Trigonelline, an alkaloid with potential antidiabetic activity, is present in Trigonella foenum-graecum L. Trigonelline is an efficient Nrf2 inhibitor capable of blocking Nrf2-dependent proteasome activity and thereby apoptosis protection in pancreatic cancer cells.
    Trigonelline
  • HY-W104368
    Nicotinic acid riboside 17720-18-2 99.50%
    Nicotinic acid riboside is a NAD+ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD+ metabolism.
    Nicotinic acid riboside
  • HY-17387
    (-)-Huperzine A 102518-79-6 99.00%
    (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease.
    (-)-Huperzine A
  • HY-N1373
    Sophoridine 6882-68-4 99.45%
    Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity.
    Sophoridine
  • HY-101400
    Deoxycytidine triphosphate 2056-98-6 98.15%
    Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
    Deoxycytidine triphosphate
  • HY-W052144
    (±) Anabasine 13078-04-1
    (±) Anabasine is a biphasic muscle relaxant.
    (±) Anabasine
  • HY-N2079
    (-)-Securinine 5610-40-2 99.65%
    (-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.
    (-)-Securinine
  • HY-B1532
    Anabasine 494-52-0 99.87%
    Anabasine ((S)-Anabasine) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC50=0.7 µM).
    Anabasine
  • HY-N2368A
    Arecaidine hydrochloride 6018-28-6
    Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake.
    Arecaidine hydrochloride
  • HY-100809
    Guvacine hydrochloride 6027-91-4 99.73%
    Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).
    Guvacine hydrochloride