486-56-6
Chemical Structure
Cotinine
Synonym(s): (-)-Cotinine;(S)-Cotinine; NIH-10498
- CAS No.: 486-56-6
- Formula:C10H12N2O
- Molecular Weight:176.22
IUPAC Name: (S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one
InChIKey: UIKROCXWUNQSPJ-VIFPVBQESA-N
SMILES: O=C1N(C)[C@H](C2=CC=CN=C2)CC1
Biological Activity: Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cotinine | 99.98% | Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases. | ||||||||||||||||||||
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Cotinine (Standard) | ≥98% | Cotinine (Standard) is the analytical standard of Cotinine. This product is intended for research and analytical applications. Cotinine ((-)-Cotinine), an alkaloid in tobacco and a major metabolite of nicotine, is used as a biological indicator to measure the composition of tobacco smoke | ||||||||||||||||||||
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(Rac)-Cotinine-d7 | (Rac)-Cotinine-d7 is deuterium labeled Cotinine. | |||||||||||||||||||||
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(Rac)-Cotinine-d4 | 99.56% | (Rac)-Cotinine-d4 is the deuterium labeled (Rac)-Cotinine. | ||||||||||||||||||||
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References
- [1]. Dolcini MM, et al. An assessment of the validity of adolescent self-reported smoking using three biological indicators. Nicotine Tob Res. 2003 Aug;5(4):473-83. [Content Brief]
- [2]. Sastry BV, et al. Distribution and retention of nicotine and its metabolite, cotinine, in the rat as a function of time. Pharmacology. 1995 Feb;50(2):128-36. [Content Brief]
- [3]. Borzelleca J F, et al. Studies on the respiratory and cardiovascular effects of (-)-cotinine[J]. Journal of Pharmacology and Experimental Therapeutics, 1962, 137(3): 313-318. [Content Brief]
- [4]. Yang Q, et al. Continuous exposure of nicotine and cotinine retards human primary pterygium cell proliferation and migration. [Content Brief]
- [5]. Dwoskin L P, et al. (S)-(−)-Cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H] dopamine release from rat striatal slices in a calcium-dependent manner[J]. Journal of pharmacology and experimental therapeutics, 1999, 288(3): 905-911. [Content Brief]
