1. PI3K/Akt/mTOR
    Stem Cell/Wnt
    MAPK/ERK Pathway
    NF-κB
  2. Akt
    ERK
    NF-κB

Tomatidine 

Cat. No.: HY-N2149 Purity: >98.0%
Data Sheet SDS Handling Instructions

Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-κB.

For research use only. We do not sell to patients.
Tomatidine Chemical Structure

Tomatidine Chemical Structure

CAS No. : 77-59-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
25 mg $50 In-stock
50 mg $80 In-stock
100 mg $140 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

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Description

Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-κB. possess anti-inflammatory properties. a novel small molecule inhibitor of muscle atrophy. target: ERK[1], Akt[1], NF-κB[1]; In vitro: Tomatidine downregulates the expression of MMP-2, -9, while increases the expression of RECK and TIMP-1. Tomatidine does not effectively inhibit the viability of A549 cells. tomatidine inhibits the invasion of A549 cells by reducing the expression of MMPs. [1] tomatidine stimulated mTORC1 signaling and anabolism, leading to accumulation of protein and mitochondria, and ultimately, cell growth. [2] tomatidine inhibits the invasion of A549 cells by reducing the expression of MMPs. [3] In vivo: in mice, tomatidine increased skeletal muscle mTORC1 signaling, reduced skeletal muscle atrophy, enhanced recovery from skeletal muscle atrophy, stimulated skeletal muscle hypertrophy, and increased strength and exercise capacity. [2]

References
Molecular Weight

415.65

Formula

C₂₇H₄₅NO₂

CAS No.

77-59-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: >98.0%

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Tomatidine
Cat. No.:
HY-N2149
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