1. NF-κB
    MAPK/ERK Pathway
  2. NF-κB
  3. Tomatidine hydrochloride

Tomatidine hydrochloride 

Cat. No.: HY-N2149A
Handling Instructions

Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans.

For research use only. We do not sell to patients.

Tomatidine hydrochloride Chemical Structure

Tomatidine hydrochloride Chemical Structure

CAS No. : 6192-62-7

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Top Publications Citing Use of Products

Publications Citing Use of MCE Tomatidine hydrochloride

    Tomatidine hydrochloride purchased from MCE. Usage Cited in: FASEB J. 2019 Feb;33(2):2574-2586.

    Tomatidine attenuates osteoclastogenesis by inhibiting the MAPK, NF-kB, and PI3K/Akt signaling pathways in vitro.

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    Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling[1]. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans[2].

    IC50 & Target[1]





    In Vitro

    Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity[1].

    Molecular Weight




    CAS No.



    Room temperature in continental US; may vary elsewhere.


    Please store the product under the recommended conditions in the Certificate of Analysis.

    Cell Assay

    RAW 264.7 cells, derived from murine macrophages, are cultured in DMEM supplemented with 10% endotoxin-free, heat-inactivated fetal calf serum, Penicillin (100 units/mL), and Streptomycin (100 μg/mL) in a 5% CO2 atmosphere at 37 °C in a humidified incubator. For all assay, cell is plated at 2×105 cells/cm2 in culture dishes or plates. Treatment with vehicle (0.1% DMSO or 0.1% ethanol), test compounds and/or LPS is carried out under serum-free conditions[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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    TomatidineNF-κBJNKAutophagyNuclear factor-κBNuclear factor-kappaBc-Jun N-terminal kinaseanti-inflammatorychemopreventionLPS-stimulatedmousemacrophagesphosphorylationInhibitorinhibitorinhibit

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