64091-91-4
64091-91-4
Chemical Structure
NNK
- CAS No.: 64091-91-4
- Formula:C10H13N3O2
- Molecular Weight:207.23
IUPAC Name: N-methyl-N-(4-oxo-4-(pyridin-3-yl)butyl)nitrous amide
InChIKey: FLAQQSHRLBFIEZ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CN=C1)CCCN(C)N=O
Biological Activity: NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα[1]. NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NNK | 99.97% | NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα. NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure. | ||||||||||||||||||||
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NNK (Standard) | 99.94% | NNK (Standard) is the analytical standard of NNK. This product is intended for research and analytical applications. NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα. NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure. | ||||||||||||||||||||
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NNK-d3 | NNK-d3 is the deuterium labeled NNK (HY-126477). | |||||||||||||||||||||
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NNK-d4 | 99.65% | NNK-d4 is the deuterium labeled NNK. | ||||||||||||||||||||
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NNK-13C6 | NNK-13C6 is the 13C-labeled NNK. | |||||||||||||||||||||
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References
- [1]. Jin Z, et al. Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation. J Biol Chem. 2004;279(38):40209-40219. [Content Brief]
- [2]. Castonguay A, et al. Lung tumorigenicity of NNK given orally to A/J mice: its application to chemopreventive efficacy studies. Exp Lung Res. 1991;17(2):485-499. [Content Brief]
