N-Methylnicotinamide-d4
Based on 1 Customer Validation
N-Methylnicotinamide-d4 is the deuterium labeled N-Methylnicotinamide (HY-124124). N-Methylnicotinamide is an endogenous metabolite with antithrombotic effect. N-Methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. N-Methylnicotinamide is also the N-methylation product from nicotinamide catalyzed by N-methyltransferase within nicotinate and nicotinamide metabolism pathway.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.0%
- CAS. Nr.: 2708278-64-0
- Formel: C7H4D4N2O
- Molecular Weight:140.18
-
Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS. Nr. 2708278-64-0
-
Unlabeled Cas 114-33-0
-
Appearance Solid
-
Molecular Weight 140.18
-
Formel C7H4D4N2O
-
Color White to off-white
-
SMILES
CNC(C1=C([2H])N=C([2H])C([2H])=C1[2H])=O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 250 mg/mL (1783.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
-
Data Sheet (273 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Rahman MS, et al. Screening and quantification of undeclared PGF2α analogs in eyelash-enhancing cosmetic serums using LC-MS/MS. J Pharm Biomed Anal. 2022 Sep 20;219:114940. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.1337 mL | 35.6684 mL | 71.3369 mL | 178.3421 mL |
| 5 mM | 1.4267 mL | 7.1337 mL | 14.2674 mL | 35.6684 mL | |
| 10 mM | 0.7134 mL | 3.5668 mL | 7.1337 mL | 17.8342 mL | |
| 15 mM | 0.4756 mL | 2.3779 mL | 4.7558 mL | 11.8895 mL | |
| 20 mM | 0.3567 mL | 1.7834 mL | 3.5668 mL | 8.9171 mL | |
| 25 mM | 0.2853 mL | 1.4267 mL | 2.8535 mL | 7.1337 mL | |
| 30 mM | 0.2378 mL | 1.1889 mL | 2.3779 mL | 5.9447 mL | |
| 40 mM | 0.1783 mL | 0.8917 mL | 1.7834 mL | 4.4586 mL | |
| 50 mM | 0.1427 mL | 0.7134 mL | 1.4267 mL | 3.5668 mL | |
| 60 mM | 0.1189 mL | 0.5945 mL | 1.1889 mL | 2.9724 mL | |
| 80 mM | 0.0892 mL | 0.4459 mL | 0.8917 mL | 2.2293 mL | |
| 100 mM | 0.0713 mL | 0.3567 mL | 0.7134 mL | 1.7834 mL |
N-Methylnicotinamide-d4 Related Classifications
HY-124124S Related Classifications
Powered by Bioz