1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. NNK

NNK 

Cat. No.: HY-126477
Handling Instructions

NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα. NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure.

For research use only. We do not sell to patients.

NNK Chemical Structure

NNK Chemical Structure

CAS No. : 64091-91-4

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Description

NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα[1]. NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure[2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

NNK (100 pM; 0-60 min) stimulates activation of PKCα and MAPKs ERK1/2 that directly induce c-Myc phosphorylation[1].
NNK (100 pM; 96 hours) enhances proliferation of cells expressing WT but not AA c-Myc mutant[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line: NCI-H82 cells[1]
Concentration: 100 pM
Incubation Time: 0-60 min
Result: Stimulated activation of PKCα and MAPKs ERK1/2 that directly induced c-Myc phosphorylation.

Apoptosis Analysis

Cell Line: H1299 lung cancer cells[1]
Concentration: 100 pM
Incubation Time: 96 hours
Result: Enhanced proliferation of cells expressing WT but not T58A/S62A c-Myc mutant.
Molecular Weight

207.23

Formula

C10H13N3O2

CAS No.
SMILES

O=C(C1=CC=CN=C1)CCCN(C)N=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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NNK
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HY-126477
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