77-59-8
77-59-8
Chemical Structure
Tomatidine
- CAS No.: 77-59-8
- Formula:C27H45NO2
- Molecular Weight:415.65
IUPAC Name: (2aS,4S,5'S,6aS,6bS,8aS,8bR,9S,10S,11aS,12aS,12bR)-5',6a,8a,9-tetramethyloctadecahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-piperidin]-4-ol
InChIKey: XYNPYHXGMWJBLV-VXPJTDKGSA-N
SMILES: [H][C@]1(O[C@]2(NC[C@@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC[C@@]6([H])C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H]
Biological Activity: Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling[1]. Tomatidine activates autophagy either in mammal cells or C elegans[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tomatidine | 98.85% | Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine activates autophagy either in mammal cells or C elegans. | ||||||||||||||||||||
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Tomatidine (Standard) | 99.83% | Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine activates autophagy either in mammal cells or C elegans. | ||||||||||||||||||||
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5α-Pregnane-3α,20α-diol | 5α-Pregnane-3α,20α-diol (Allopregnanediol) is a derivative of progesterone and is one of the various steroids secreted by the ovaries of rats. 5α-Pregnane-3α,20α-diol can significantly stimulate the release of luteinizing hormone (LH) in castrated rats that have been pre-treated with estrogen, while simultaneously inhibiting the secretion of follicle-stimulating hormone (FSH). | |||||||||||||||||||||
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Jurubidine | Jurubidine is a novel and potent cyclised aglycone. | |||||||||||||||||||||
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Solasodine | 99.97% | Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities. | ||||||||||||||||||||
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Solasodiene | 99.86% | Solasodiene is an alkaloid. Solasodiene can be isolated from fruits collected in Mozambique. | ||||||||||||||||||||
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Solanaviol | Solanaviol is a spirosolane-type steroidal alkaloid found in the leaves of Solanum aviculare. Alkaloids are a large class of complex nitrogen-containing basic organic compounds. As food, nutritional supplements, and medicines, alkaloids play an important role in medicine and other fields. Alkaloid compounds exhibit good biological activities in anti-inflammatory, anticancer, analgesic, local anesthetic, neuropharmacological, antibacterial, and antifungal properties. | |||||||||||||||||||||
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Tomatidine hydrochloride | 99.70% | Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans. | ||||||||||||||||||||
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Demissidine | 95% | Demissidine is an alkaloid aglycone that can be isolated from Solanum tuberosum. Demissidine is a dual inhibitor candidate that shows activity against β-secretase and γ-secretase in silico. Demissidine has antibacterial and antiparasitic activities. Demissidine also has weak anticancer and acetylcholinesterase (AChE) inhibitory activities. Demissidine can be used in research on colon cancer, liver cancer, Alzheimer's disease, and Chagas disease. | ||||||||||||||||||||
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Soladulcidine | Soladulcidine, as an anticancer steroidal alkaloid, possesses antifungal and induction of congenital craniofacial malformation activities. | |||||||||||||||||||||
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Solasodine hydrochloride | Solasodine (Purapuridine) hydrochloride is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine hydrochloride induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine hydrochloride has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities. | |||||||||||||||||||||
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References
- [1]. Chiu FL, et al. Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages. FEBS Lett. 2008 Jul 9;582(16):2407-12. [Content Brief]
- [2]. Anil Ahsan, et al. Tomatidine Protects Against Ischemic Neuronal Injury by Improving Lysosomal Function. Eur J Pharmacol. 2020 Jun 21;173280. [Content Brief]
