2. Apoptosis Anti-infection Metabolic Enzyme/Protease
  3. MDM-2/p53 Fungal E1/E2/E3 Enzyme Apoptosis
  4. Solasodine

Solasodine  (Synonyms: Purapuridine; Solancarpidine; Solasodin)

Cat. No.: HY-N0068 Purity: 99.54%
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COA
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Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities.

For research use only. We do not sell to patients.

Solasodine Chemical Structure

Solasodine Chemical Structure

CAS No. : 126-17-0

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Solution
10 mM * 1 mL in Ethanol In-stock
Solid
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Based on 3 publication(s) in Google Scholar

Other Forms of Solasodine:

Solasodine Related Antibodies

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  • Purity & Documentation

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Description

Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities[1][2][3].

In Vitro

Solasodine (90 μM; 2 days) treatment displays significant sprouting in P19 cells. Solasodine induces strong expression of the different neuronal markers studied, including βIII-tubulin, synaptophysin, MAP2, ChAT, and neuroblast marker doublecortin. Solasodine induces the differentiation of P19 cells, essentially towards the neuronal pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Solasodine Related Antibodies
In Vivo

Solasodine (25-100 mg/kg; intraperitoneal injection; once) treatment significantly delays latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiates Thiopental-provoked sleep in a dose-dependent manner. Solasodine has anticonvulsant and CNS depressant activities[2].
Solasodine (375 μM; i.c.v.; for 2 weeks) treatment results a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining. Solasodine treatment in rats results in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice (18-25 g) treated with Picrotoxin (PCT) or Thiopental[2]
Dosage: 25 mg/kg, 50 mg/kg and 100 mg/kg
Administration: Intraperitoneal injection; once
Result: Significantly delayed latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiated Thiopental-provoked sleep in a dose-dependent manner.
Clinical Trial
Molecular Weight

413.64

Formula

C27H43NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](CC1)CN[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

Ethanol : 20 mg/mL (48.35 mM; Need ultrasonic)

DMSO : 1.96 mg/mL (4.74 mM; ultrasonic and warming and adjust pH to 5 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4176 mL 12.0878 mL 24.1756 mL
5 mM 0.4835 mL 2.4176 mL 4.8351 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.54%

SDS (393 KB)

COA (251 KB) HNMR (292 KB) RP-HPLC (216 KB) MS (68 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 2.4176 mL 12.0878 mL 24.1756 mL 60.4390 mL
Ethanol 5 mM 0.4835 mL 2.4176 mL 4.8351 mL 12.0878 mL
10 mM 0.2418 mL 1.2088 mL 2.4176 mL 6.0439 mL
15 mM 0.1612 mL 0.8059 mL 1.6117 mL 4.0293 mL
20 mM 0.1209 mL 0.6044 mL 1.2088 mL 3.0220 mL
25 mM 0.0967 mL 0.4835 mL 0.9670 mL 2.4176 mL
30 mM 0.0806 mL 0.4029 mL 0.8059 mL 2.0146 mL
40 mM 0.0604 mL 0.3022 mL 0.6044 mL 1.5110 mL
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Solasodine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Solasodine126-17-0Purapuridine Solancarpidine SolasodinMDM-2/p53FungalE1/E2/E3 EnzymeApoptosisE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseNeuroprotective sβIII-tubulindoublecortinsteroidalalkaloidantifungalhypotensiveanticancerantiatheroscleroticanti-inflammatoryInhibitorinhibitorinhibit

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