Solasodine  (Synonyms: Purapuridine; Solancarpidine; Solasodin)

Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities^[1][2].

Solasodine (90 μM; 2 days) treatment displays significant sprouting in P19 cells. Solasodine induces strong expression of the different neuronal markers studied, including βIII-tubulin, synaptophysin, MAP2, ChAT, and neuroblast marker doublecortin. Solasodine induces the differentiation of P19 cells, essentially towards the neuronal pathway^[1]. Solasodine induce apoptosis by inhibiting the p53-MDM2 complex, p21^Waf1/Cip1, and Bcl-2 proteins^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Solasodine (25-100 mg/kg; intraperitoneal injection; once) treatment significantly delays latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiates Thiopental-provoked sleep in a dose-dependent manner. Solasodine has anticonvulsant and CNS depressant activities^[2].
Solasodine (375 μM; i.c.v.; for 2 weeks) treatment results a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining. Solasodine treatment in rats results in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

413.64

Solid

C₂₇H₄₃NO₂

126-17-0

C[[email protected]](CC1)CN[[email protected]]21O[[email protected]@]3([H])C[[email protected]@]4([H])[[email protected]]5([H])CC=C6C[[email protected]@H](O)CC[[email protected]]6(C)[[email protected]@]5([H])CC[[email protected]]4(C)[[email protected]@]3([H])[[email protected]@H]2C

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Lecanu L, et al. The naturally occurring steroid solasodine induces neurogenesis in vitro and in vivo. Neuroscience. 2011 Jun 2;183:251-64.  [Content Brief]

  [2]. Chauhan K, et al. Anticonvulsant activity of solasodine isolated from Solanum sisymbriifolium fruits in rodents. Pharm Biol. 2011 Feb;49(2):194-9.  [Content Brief]

  [3]. Akhtar S, et al. Evaluation and Elucidation Studies of Natural Aglycones for Anticancer Potential using Apoptosis-Related Markers: An In silico Study. Interdiscip Sci. 2018 Jun;10(2):297-310.  [Content Brief]

  [4]. Gupta RS, et al. Effects of short-term treatment of solasodine on cauda epididymis in dogs. Indian J Exp Biol. 2002 Feb;40(2):169-73.  [Content Brief]