1. Apoptosis
    Anti-infection
    Metabolic Enzyme/Protease
  2. MDM-2/p53
    Fungal
    E1/E2/E3 Enzyme
    Apoptosis
  3. Solasodine

Solasodine  (Synonyms: Purapuridine; Solancarpidine; Solasodin)

Cat. No.: HY-N0068 Purity: ≥98.0%
COA Handling Instructions

Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities.

For research use only. We do not sell to patients.

Solasodine Chemical Structure

Solasodine Chemical Structure

CAS No. : 126-17-0

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10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 150 In-stock
Estimated Time of Arrival: December 31
100 mg USD 260 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Solasodine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities[1][2].

In Vitro

Solasodine (90 μM; 2 days) treatment displays significant sprouting in P19 cells. Solasodine induces strong expression of the different neuronal markers studied, including βIII-tubulin, synaptophysin, MAP2, ChAT, and neuroblast marker doublecortin. Solasodine induces the differentiation of P19 cells, essentially towards the neuronal pathway[1]. Solasodine induce apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Solasodine (25-100 mg/kg; intraperitoneal injection; once) treatment significantly delays latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiates Thiopental-provoked sleep in a dose-dependent manner. Solasodine has anticonvulsant and CNS depressant activities[2].
Solasodine (375 μM; i.c.v.; for 2 weeks) treatment results a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining. Solasodine treatment in rats results in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice (18-25 g) treated with Picrotoxin (PCT) or Thiopental[2]
Dosage: 25 mg/kg, 50 mg/kg and 100 mg/kg
Administration: Intraperitoneal injection; once
Result: Significantly delayed latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiated Thiopental-provoked sleep in a dose-dependent manner.
Clinical Trial
Molecular Weight

413.64

Appearance

Solid

Formula

C27H43NO2

CAS No.
SMILES
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 2.6 mg/mL (6.29 mM; Need ultrasonic)

H2O : 0.67 mg/mL (1.62 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4176 mL 12.0878 mL 24.1756 mL
5 mM 0.4835 mL 2.4176 mL 4.8351 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Solasodine
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HY-N0068
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