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Piperlongumine

(Synonyms: Piplartine)
14 Cited Publications
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Based on 14 publication(s) in Google Scholar

Piperlongumine is a alkaloid, possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome.

For research use only. We do not sell to patients.

  • Purity: 99.86%
  • CAS No.: 20069-09-4
  • Formula: C17H19NO5
  • Molecular Weight:317.34
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Piperlongumine Chemical Structure
    Piperlongumine Chemical Structure
  • Experimental Validation Results for Piperlongumine
  • Experimental Validation Results for Piperlongumine
  • Experimental Validation Results for Piperlongumine
  • Experimental Validation Results for Piperlongumine
  • Experimental Validation Results for Piperlongumine
  • Experimental Validation Results for Piperlongumine
  • Experimental Validation Results for Piperlongumine
  • Experimental Validation Results for Piperlongumine
CAS No.: 20069-09-4
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  • Piperlongumine Chemical Structure
    Piperlongumine Chemical Structure
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    Piperlongumine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec 23:e17792. [Abstract]

    Customer Validation
     Dose‐response curves and IC50 values of DOX and Piperlongumine (PL, 24 h) against HCCLM3 and Hepa1‐6 cells.

  • 1/16

    Piperlongumine purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156606. [Abstract]

    Customer Validation
     Piperlongumine (PL, 10 mg/kg; i.p.; once every two days for 7 days) significantly improved body weight and survival rate in mice following CVB3 infection.

  • 1/16

    Piperlongumine purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156606. [Abstract]

    Customer Validation
     Piperlongumine (PL, 10 mg/kg; i.p.; once every two days for 7 days) significantly alleviated CVB3-induced myocardial injury in mice.

  • 1/16

    Piperlongumine purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156606. [Abstract]

    Customer Validation
     Statistical analysis of TNF-α, IL-1β, IL-6, and MCP-1 mRNA expression levels in mouse hearts of each group using RT-qPCR (n = 3). The expression levels were expressed as ratio relative to GAPDH. The results showed that Piperlongumine (PL, 10 mg/kg; i.p.; once every two days for 7 days) significantly attenuated the CVB3-induced upregulation of IL-1β, IL-6, TNF-α and MCP-1 in mice.

  • 1/16

    Piperlongumine purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156606. [Abstract]

    Customer Validation
     HL-1 cells were treated with indicated doses of Piperlongumine (PL, 0.625-160 µM) for 24 h. The cell viability rate was calculated by CCK-8 assay. The results indicated that PL did not affect HL-1 cell proliferation at concentrations of 20 µM or less.

  • 1/16

    Piperlongumine purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156606. [Abstract]

    Customer Validation
     Total protein of treated HL-1 cells was analyzed by western blotting. The relative levels of pyroptosis related proteins were normalized to that of GAPDH (n = 3). The results demonstrated that Piperlongumine (PL, 10 µM; 24 h) attenuated CVB3-induced cardiomyocyte pyroptosis in vitro.

  • 1/16

    Piperlongumine purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156606. [Abstract]

    Customer Validation
     Piperlongumine (PL, 10 µM; 24 h) reversed the increased expression and aggregation of the N‑terminal fragment of gasdermin D (GSDMD‑N) induced by CVB3 in HL‑1 cells.

  • 1/16

    Piperlongumine purchased from MedChemExpress. Usage Cited in: Transl Cancer Res. 2023 Oct 31;12(10):2911-2922. [Abstract]

    Customer Validation
     Piperlongumine (PL) affectes the expression of ferroptosis related proteins in OSCC cells. PL (6, 12, 24 h) increases the expression of DMT1 in OSCC cells, and decreases the expression of FTH1, SLC7A11 and GPX4.

  • Piperlongumine