1. PI3K/Akt/mTOR
    Autophagy
    NF-κB
    Metabolic Enzyme/Protease
    Immunology/Inflammation
    Apoptosis
  2. PI3K
    Autophagy
    Mitophagy
    Reactive Oxygen Species
    Apoptosis
  3. Quercetin

Quercetin 

Cat. No.: HY-18085 Purity: >98.0%
Handling Instructions

Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

For research use only. We do not sell to patients.

Quercetin Chemical Structure

Quercetin Chemical Structure

CAS No. : 117-39-5

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10 mM * 1 mL in DMSO USD 55 In-stock
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Customer Review

Based on 10 publication(s) in Google Scholar

Other Forms of Quercetin:

Top Publications Citing Use of Products

    Quercetin purchased from MCE. Usage Cited in: Life Sci. 2020 Jul 20;118116.

    NRK-52E cells are treated with Quercetin (Quer, 20 μM) for 2 h prior to incubation with AngII (100 nM) for another 72 h. The expression of p21 and p16ink4a are detected using Western blotting, and quantitative analyses are performed.
    • Biological Activity

    • Protocol

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    • References

    • Customer Review

    Description

    Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

    IC50 & Target[1]

    PI3Kδ

    2.4 μM (IC50)

    PI3Kγ

    3 μM (IC50)

    PI3Kβ

    5.4 μM (IC50)

    Autophagy

     

    Mitophagy

     

    In Vitro

    Quercetin is a type of plant-based chemical, or phytochemical, used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin is a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin strongly abrogates PI3K and Src kinases, mildly inhibits Akt1/2, and slightly affected PKC, p38 and ERK1/2[1]. Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation[2].

    In Vivo

    Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth[3].

    Clinical Trial
    Molecular Weight

    302.24

    Formula

    C₁₅H₁₀O₇

    CAS No.

    117-39-5

    SMILES

    OC1=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (330.86 mM)

    Ethanol : 10 mg/mL (33.09 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.3086 mL 16.5431 mL 33.0863 mL
    5 mM 0.6617 mL 3.3086 mL 6.6173 mL
    10 mM 0.3309 mL 1.6543 mL 3.3086 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  0.5% CMC-Na/saline water

      Solubility: 25 mg/mL (82.72 mM); Suspended solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

    • 4.

      Add each solvent one by one:  50% PG  50% Saline

      Solubility: 10 mg/mL (33.09 mM); Suspended solution; Need ultrasonic

    • 5.

      Add each solvent one by one:  50%PG  50%Saline

      Solubility: 10 mg/mL (33.09 mM); Suspended solution; Need ultrasonic

    *All of the co-solvents are provided by MCE.
    References
    Animal Administration
    [3]

    Mice are inoculated subcutaneously with 5×105 PC-3 cells suspended in 100μL PBS and 2×108 LNCaP cells suspended in 100μL of matrigel and PBS mixture (1:1) on the right back. When xenograft tumors reach a volume of approximately 100 mm3, mice are randomLy assigned to four groups (n=8 each group) and treated intraperitoneally. Therapeutic schedule based on our in vitro results, preliminary experiments and many other researchers' studies is as follows: (1) Vehicle control group: vehicle of quercetin on day 1, vehicle of 2-ME on day 2, (2) Quercetin treated group: quercetin 75 mg/kg on day 1, vehicle of 2-ME on day 2, (3) 2-ME treated group: vehicle of quercetin on day 1, 2-ME 150 mg/kg on day 2, (4) Combination treatment group: quercetin 75 mg/kg on day 1, 2-ME 150 mg/kg on day 2. Two days is a treatment cycle and the whole treatment process lasted for 4 weeks. Tumor sizes are monitored every 2 days using caliper and tumor volume are calculated according to the formula: L×S2×0.5, in which L represents the longest diameter and S represents the shortest diameter of tumor. Mice are weighed as well. At the end of treatment procedure, on day 29, mice are anesthetized with chloral hydrate and sacrificed by cervical dislocation. Xenograft tumors are taken out quickly and weighed. One part of it is put into liquid nitrogen immediately for future biomarker analysis and the other part is fixed in 10% neutral buffered formalin for immunohistochemical analysis. Serum biochemical parameters such as ALT, AST, creatinine and urea nitrogen that reflected drug toxicity are also detected.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References

    Purity: >98.0%

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    Keywords:

    QuercetinPI3KAutophagyMitophagyReactive Oxygen SpeciesApoptosisPhosphoinositide 3-kinaseMitochondrial AutophagyInhibitorinhibitorinhibit

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    Cat. No.:
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